Evidence map›Paper›PMID 25591022›Full record

ArticleJournal of applied oral science : revista FOB

Immunolocalization of markers for bone formation during guided bone regeneration in osteopenic rats.

Tábata de Mello Tera, Rodrigo Dias Nascimento, Renata Falchete do Prado, Mauro Pedrine Santamaria, Maria Aparecida Neves Jardini

Open access · diamondAbstract readEvaluation Study
In one paragraph

Article in Journal of applied oral science : revista FOB. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
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  3. Additional Insights Into the Role of Osteocalcin in Osteoblast Differentiation and in the Early Steps of Developing Alveolar Process of Rat Molars.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Tábata de Mello TeraDepartment of Bioscience and Oral Diagnosis, Instituto de Ciência e Tecnologia, Univ. Estadual Paulista, São José dos Campos, SP, Brazil.
Rodrigo Dias NascimentoDepartment of Diagnosis and Surgery, Instituto de Ciência e Tecnologia, Univ. Estadual Paulista, São José dos Campos, SP, Brazil.
Renata Falchete do PradoDepartment of Bioscience and Oral Diagnosis, Instituto de Ciência e Tecnologia, Univ. Estadual Paulista, São José dos Campos, SP, Brazil.
Mauro Pedrine SantamariaDepartment of Diagnosis and Surgery, Instituto de Ciência e Tecnologia, Univ. Estadual Paulista, São José dos Campos, SP, Brazil.
Maria Aparecida Neves JardiniDepartment of Diagnosis and Surgery, Instituto de Ciência e Tecnologia, Univ. Estadual Paulista, São José dos Campos, SP, Brazil.
Universidade Estadual Paulista (Unesp) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this paper was to evaluate the repair of onlay autogenous bone grafts covered or not covered by an expanded polytetrafluoroethylene (e-PTFE) membrane using immunohistochemistry in rats with induced estrogen deficiency. MATERIAL AND

methodsEighty female rats were randomly divided into two groups: ovariectomized (OVX) and with a simulation of the surgical procedure (SHAM). Each of these groups was again divided into groups with either placement of an autogenous bone graft alone (BG) or an autogenous bone graft associated with an e-PTFE membrane (BGM). Animals were euthanized on days 0, 7, 21, 45, and 60. The specimens were subjected to immunohistochemistry for bone sialoprotein (BSP), osteonectin (ONC), and osteocalcin (OCC).

resultsAll groups (OVX+BG, OVX+BMG, SHAM+BG, and SHAM+BMG) showed greater bone formation, observed between 7 and 21 days, when BSP and ONC staining were more intense. At the 45-day, the bone graft showed direct bonding to the recipient bed in all specimens. The ONC and OCC showed more expressed in granulation tissue, in the membrane groups, independently of estrogen deficiency.

conclusionsThe expression of bone forming markers was not negatively influenced by estrogen deficiency. However, the markers could be influenced by the presence of the e-PTFE membrane.

Indexed as

AnimalsBiomarkersBone RegenerationBone TransplantationEstrogensFemaleGuided Tissue RegenerationImmunohistochemistryIntegrin-Binding SialoproteinMandibleOsteoblastsOsteocalcinOsteonectinOsteoporosisOvariectomyPolytetrafluoroethyleneBiomarkersEstrogensIntegrin-Binding SialoproteinOsteocalcinOsteonectinPolytetrafluoroethylene

Identifiers

PMID25591022
PMCPMC4307769
OpenAlexW1996103172

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.