ArticleJournal of applied oral science : revista FOB
Oral potentially malignant disorders in a large dental population.
Article in Journal of applied oral science : revista FOB. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Prevalence of oral submucous fibrosis across diverse populations: a systematic review and meta-analysis.PeerJ · 2024Pooled it
- Immunological Analysis of Oral Cytobrush Specimens for Early Detection of Oral Cancer Biomarkers: A Comprehensive Review.International journal of molecular sciences · 2026Review
- FAP promotes progression of oral leukoplakia via activation of PI3K/AKT pathway by interacting with ITGB1.Translational oncology · 2025Article
- Investigating the association between tobacco use and oral health among security guards at a tertiary healthcare centre in New Delhi: a cross-sectional study.Frontiers in oral health · 2024Article
- Article
- Assessing the Effect of Curcumin on the Oral Mucosal Cytomorphometry and Candidal Species Specificity in Tobacco Users: A Pilot Study.Healthcare (Basel, Switzerland) · 2022Article
- Evaluation of head and neck cancer education at European dental schools.European journal of dental education : official journal of the Association for Dental Education in Europe · 2022Article
- High prevalence of oral potentially malignant disorders and risk factors in a semi-urban brazilian city: a population-based cross-sectional study.Medicina oral, patologia oral y cirugia bucal · 2021Article
- Oral potentially malignant disorders: clinical-pathological study of 684 cases diagnosed in a Brazilian population.Medicina oral, patologia oral y cirugia bucal · 2020Article
- Potential Metabolic Biomarkers for Early Detection of Oral Lichen Planus, a Precancerous Lesion.Frontiers in pharmacology · 2020Article
- Bacterial alterations in salivary microbiota and their association in oral cancer.Scientific reports · 2017Article
- Smokeless tobacco and oral potentially malignant disorders in South Asia: a protocol for a systematic review.Systematic reviews · 2016Article
- Prevalence of Human Papilloma virus in potentially malignant oral disorders is a risk factor for development of early dysplasia-A cytological investigation.Pakistan journal of medical sciencesArticle
- Simulation Modeling of Oral Cancer Development with Risk Stratification: How Potential Screening Programs Can Be Evaluated.MDM policy & practiceArticle
- In situ carcinoma developed over oral lichen planus: a case report with analysis of BUB3, p16, p53, Ki67 and SOX4 expression.Journal of applied oral science : revista FOBArticle
- Assessment of the oral cancer control activities through care seeking behavior of hospital attendees and their level of awareness.Journal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesOral cancer (OC) may be preceded by clinically evident oral potentially malignant disorders (OPMDs). Oral carcinogenesis is a multistep process that begins as epithelial hyperplasia and progresses to oral epithelial dysplasia and finally to fully malignant phenotypes. The aim of our study was to estimate the prevalence of OPMDs in a large population of dental patients.
methodsPatients were seen in the Oral Diagnosis and Oral Medicine clinics at Boston University Henry M. Goldman School of Dental Medicine between July 2013 and February 2014 and received a comprehensive oral examination to identify any possible mucosal lesions. Patients with a suspected OPMD (submucous fibrosis, oral lichen planus, leukoplakia and erythroplakia) that did not resolve in 2-3 weeks received a biopsy for definitive diagnosis. Logistic regression models were used to explore the relationship between OPMDs and associated risk factors.
resultsA total of 3,142 patients received a comprehensive oral examination [median age: 43 (range: 18-97); 54.3% females]. Among these, 4.5% had an oral mucosal lesion with 0.9% being an OPMD (one submucous fibrosis, three epithelial dysplasias, fourteen with hyperkeratosis/epithelial hyperplasia and nine with oral lichen planus). Males and current smokers were associated with higher odds of having OPMD (OR 1.7, 95% CI 0.8-3.8; OR 1.9, 95% CI 0.8-4.1). Increasing age was associated with having OPMDs (p<0.01).
conclusionOptimal oral visual screening for OC remains a simple and essential tool to identify any suspicious lesions and potentially increase survival. Although OPMDs were rare, our results confirm the importance of a thorough chairside screening by dentists and dental students to detect any mucosal changes.
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