Trial reportArquivos brasileiros de cardiologia2014
Improving post-discharge medication adherence in patients with CVD: a pilot randomized trial.
Trial report in Arquivos brasileiros de cardiologia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Consultation-based interventions to optimize medication adherence in primary care: a systematic review.Family practice · 2026Pooled it
- Patient- and family-centred care transition interventions for adults: a systematic review and meta-analysis of RCTs.International journal for quality in health care : journal of the International Society for Quality in Health Care · 2023Pooled it
- Interventions to Improve Communication at Hospital Discharge and Rates of Readmission: A Systematic Review and Meta-analysis.JAMA network open · 2021Pooled it
- Interventions for improving medication-taking ability and adherence in older adults prescribed multiple medications.The Cochrane database of systematic reviews · 2020Pooled it
- Video-based teach-to-goal intervention on inhaler technique on adults with asthma and COPD: A randomized controlled trial.PloS one · 2023Trial
- Effect of text messages to improve health literacy on medication adherence in patients with type 2 diabetes mellitus: A randomized controlled pilot trial.Nagoya journal of medical science · 2017Trial
- "Know your medicines, know your health"-public perspectives on medicines and health awareness campaigns.Frontiers in public health · 2025Article
- The Association Between Medication Non-Adherence and Early and Late Readmission Rates for Patients with Acute Coronary Syndrome.International journal of general medicine · 2022Article
- Medication Supports at Transitions Between Hospital and Other Care Settings: A Rapid Scoping Review.Patient preference and adherence · 2022Article
- Hospital Readmissions after Acute Coronary Syndromes.Arquivos brasileiros de cardiologia · 2019Article
- A perspective on nonadherence to drug therapy: psychological barriers and strategies to overcome nonadherence.Patient preference and adherence · 2018Review
- Pharmacist-Led Intervention to Enhance Medication Adherence in Patients With Acute Coronary Syndrome in Vietnam: A Randomized Controlled Trial.Frontiers in pharmacology · 2018Article
- The prevalence of medication nonadherence in post-myocardial infarction survivors and its perceived barriers and psychological correlates: a cross-sectional study in a cardiac health facility in Malaysia.Patient preference and adherence · 2017Article
- Analyzing cardiovascular treatment guidelines application to women and minority populations.SAGE open medicine · 2017Review
- Improving Patient's Primary Medication Adherence: The Value of Pharmaceutical Counseling.Medicine · 2015Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEffective interventions to improve medication adherence are usually complex and expensive.
objectiveTo assess the impact of a low-cost intervention designed to improve medication adherence and clinical outcomes in post-discharge patients with CVD.
methodA pilot RCT was conducted at a teaching hospital. Intervention was based on the four-item Morisky Medication Adherence Scale (MMAS-4). The primary outcome measure was medication adherence assessed using the eight-item MMAS at baseline, at 1 month post hospital discharge and re-assessed 1 year after hospital discharge. Other outcomes included readmission and mortality rates.
results61 patients were randomized to intervention (n = 30) and control (n = 31) groups. The mean age of the patients was 61 years (SD 12.73), 52.5% were males, and 57.4% were married or living with a partner. Mean number of prescribed medications per patient was 4.5 (SD 3.3). Medication adherence was correlated to intervention (p = 0.04) and after 1 month, 48.4% of patients in the control group and 83.3% in the intervention group were considered adherent. However, this difference decreased after 1 year, when adherence was 34.8% and 60.9%, respectively. Readmission and mortality rates were related to low adherence in both groups.
conclusionThe intervention based on a validated patient self-report instrument for assessing adherence is a potentially effective method to improve adherent behavior and can be successfully used as a tool to guide adherence counseling in the clinical visit. However, a larger study is required to assess the real impact of intervention on these outcomes.
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