ArticleCell cycle (Georgetown, Tex.)2015
Active contractility at E-cadherin junctions and its implications for cell extrusion in cancer.
Article in Cell cycle (Georgetown, Tex.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- Basal Invasion of Cancer Cells Driven by Cell-Cell Interactions: An Affirmative Role of Cell Competition in Cancer Progression.Cancer science · 2025Review
- Cell extrusion drives neural crest cell delamination.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Identification and validation of a prognostic model based on four genes related to satellite nodules in hepatocellular carcinoma.Scientific reports · 2024Article
- MicroRNAs Can Influence Ovarian Cancer Progression by Dysregulating Integrin Activity.Cancers · 2023Review
- Article
- Ret kinase-mediated mechanical induction of colon stem cells by tumor growth pressure stimulates cancer progression in vivo.Communications biology · 2022Article
- Lung Cancer Induces NK Cell Contractility and Cytotoxicity Through Transcription Factor Nuclear Localization.Frontiers in cell and developmental biology · 2022Article
- OncogenicScience advances · 2021Article
- Desmosomes polarize and integrate chemical and mechanical signaling to govern epidermal tissue form and function.Current biology : CB · 2021Article
- MRCK: a master regulator of tissue remodeling or another 'ROCK' in the epithelial block?Tissue barriers · 2021Review
- Adhesion-mediated heterogeneous actin organization governs apoptotic cell extrusion.Nature communications · 2021Article
- Mechanoregulation of PDZ Proteins, An Emerging Function.Methods in molecular biology (Clifton, N.J.) · 2021Review
- Scaling up single-cell mechanics to multicellular tissues - the role of the intermediate filament-desmosome network.Journal of cell science · 2020Review
- Review
- aPKCi triggers basal extrusion of luminal mammary epithelial cells by tuning contractility and vinculin localization at cell junctions.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Death for life: a path from apoptotic signaling to tissue-scale effects of apoptotic epithelial extrusion.Cellular and molecular life sciences : CMLS · 2019Review
- Actin dynamics and the Bmp pathway drive apical extrusion of proepicardial cells.Development (Cambridge, England) · 2019Article
- Curvature-dependent constraints drive remodeling of epithelia.Journal of cell science · 2019Article
- Spatio-Temporal Regulation of RhoGTPases Signaling by Myosin II.Frontiers in cell and developmental biology · 2019Review
- Force transduction by cadherin adhesions in morphogenesis.F1000Research · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellular contractility regulates tissue cohesion and morphogenesis. In epithelia, E-cadherin adhesion couples the contractile cortices of neighboring cells together to produce tension at junctions that can be transmitted across the epithelium in a planar fashion. We have recently demonstrated that contractility is also patterned in the apical-lateral axis within epithelial junctions. Our findings highlight the role that cytoskeletal regulation plays in controlling the levels of intra-junctional tension. Of note, dysregulation of this apicolateral pattern of tension can drive oncogenic cell extrusion. In this article, we provide a detailed description of the actomyosin cytoskeleton organization during oncogenic extrusion and discuss the implications of cell extrusion in cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.