Evidence map›Paper›PMID 25590756›Full record

ArticleCell host & microbe2015

PfEMP1's magical embrace of EPCR.

Rick M Fairhurst

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell host & microbe, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Rick M FairhurstLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Room 3E-10A, Rockville, MD 20852, USA. Electronic address: rfairhurst@niaid.nih.gov.

Funding

Malaria Pathogenesis and Human ImmunityZIAAI001000 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI FAIRHURST, RICK · 2009 to 2017
$9.3M
Intramural NIH HHS
6 · The paper itself

Abstract

Since discovering PfEMP1 virulence proteins in Plasmodium falciparum, malariologists have struggled to reconcile their limitless sequence diversity with their binding to relatively few host receptors. In this issue of Cell Host & Microbe, Lau et al. (2015) explore how diverse PfEMP1s embrace EPCR, promoting parasite survival and killing African children.

Indexed as

Genetic VariationHost-Pathogen InteractionsAntigens, CDFemaleHumansMaleProtozoan ProteinsReceptors, Cell SurfaceAntigens, CDProtozoan ProteinsReceptors, Cell Surface

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.