Trial reportJournal of bronchology & interventional pulmonology2015
Confocal laser endomicroscopy for diagnosis and monitoring of pulmonary alveolar proteinosis.
Trial report in Journal of bronchology & interventional pulmonology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Pathway-specific mechanisms, therapeutic applications, and toxicodynamic profile of acriflavine in cancer: a comprehensive review.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Application of confocal laser endomicroscopy in the diagnosis of peripheral pulmonary lesions: a narrative review.Journal of thoracic disease · 2026Review
- Vaporization of perfluorocarbon attenuates sea-water-drowning-induced acute lung injury by deactivating the NLRP3 inflammasomes in canines.Experimental biology and medicine (Maywood, N.J.) · 2024Article
- Optical Biopsies Using Probe-Based Confocal Laser Endomicroscopy for Autoimmune Pulmonary Alveolar Proteinosis.Respiration; international review of thoracic diseases · 2024Article
- The cryobiopsy in interstitial lung diseases guided by probe-based confocal laser endomicroscopy is feasible.The clinical respiratory journal · 2023Article
- The role of confocal laser endomicroscopy in pulmonary medicine.European respiratory review : an official journal of the European Respiratory Society · 2023Review
- Bronchoscopic Probe-Based Confocal Laser Endomicroscopy to Diagnose Diffuse Parenchymal Lung Diseases.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2022Article
- Hybrid Agent-Based Modeling ofFrontiers in microbiology · 2020Article
- Novel Imaging Approaches in Systemic Sclerosis-Associated Interstitial Lung Disease.Current rheumatology reports · 2019Review
- Probe-based confocal laser endomicroscopy of the airways: physiological and pathological characteristics of preneoplastic and neoplastic lesions.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2019Article
- Identification of Bronchoalveolar Lavage Components Applying Confocal Laser Endomicroscopy.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Fibred confocal fluorescence microscopy in the diagnosis of interstitial lung diseases.Journal of thoracic disease · 2016Article
- The role of bronchoscopy in the diagnosis of early lung cancer: a review.Journal of thoracic disease · 2016Review
- Advances in Optical Coherence Tomography and Confocal Laser Endomicroscopy in Pulmonary Diseases.Respiration; international review of thoracic diseasesReview
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe diagnosis of pulmonary alveolar proteinosis (PAP) is based on computed tomography, histology, and antibodies to granulocyte-macrophage colony-stimulating factor. The role of a novel technique for imaging cells and elastin during endoscopy, probe-based confocal laser endomicroscopy (pCLE), has not yet been investigated in PAP patients. The aim of the present study was to estimate the value of pCLE in the PAP diagnosis and treatment in comparison with the findings of high-resolution computed tomography (HRCT) before and after whole-lung lavage.
methodsIn vivo pCLE was performed during bronchoscopy in 6 male patients with PAP before and after whole-lung lavage. In certain lung segments, pCLE was followed by HRCT.
resultsDuring the in vivo pCLE, we found characteristic signs of PAP: a fluorescent floating amorphous substance in the alveoli lumen sticking to conglomerates along with alveolar macrophages. These features were present to a lesser extent after a whole-lung lavage. pCLE revealed specific PAP features not only in segments with crazy-paving and ground-glass opacity, but also in segments without HRCT findings.
conclusionsThe alveolar imaging in PAP patients is able to reveal characteristic changes, both in the presence and in the absence of HRCT findings. Therefore, pCLE may be a helpful tool for the diagnosis and whole-lung lavage therapy. Our data prove that accumulation of lipoproteinaceous substances within the alveoli at PAP is a diffuse but not a patchy process.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.