ArticlePLoS neglected tropical diseases2015
Bartonella spp. bacteremia in blood donors from Campinas, Brazil.
Article in PLoS neglected tropical diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.
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Who cites it
61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Bartonellosis in World Health Organization Eastern Mediterranean Region, a systematic review and meta-analysis.European journal of public health · 2025Pooled it
- The Global Molecular Prevalence ofTransboundary and emerging diseases · 2023Pooled it
- Molecular identification of Bartonella henselae in dogs with clinical suspicion of visceral leishmaniasis.Revista do Instituto de Medicina Tropical de Sao Paulo · 2026Article
- Beyond Bartonellosis: A Case Report of Hepatic Tuberculosis as a Final Diagnosis in a Child With Down Syndrome.Case reports in infectious diseases · 2026Article
- Article
- Molecular Survey of Hemopathogens in Dogs, Including Blood Donors, from Central-Western Brazil.Pathogens (Basel, Switzerland) · 2025Article
- Rabies virus, Bartonella koehlerae and Leishmania infantum coinfection in a black Myotis (Myotis nigricans) from southeastern Brazil.Veterinary research communications · 2025Article
- Multi systemic compromise due to Bartonella henselae in a child.Revista do Instituto de Medicina Tropical de Sao Paulo · 2025Article
- Neurobartonelloses: emerging from obscurity!Parasites & vectors · 2024Review
- Viable but nonculturable state in the zoonotic pathogenFrontiers in cellular and infection microbiology · 2024Article
- Blood Supplementation Enhances Bartonella henselae Growth and Molecular Detection of Bacterial DNA in Liquid Culture.Microbiology spectrum · 2023Article
- Comparison of molecular methods for Bartonella henselae detection in blood donors.PLoS neglected tropical diseases · 2023Article
- Two novelFrontiers in microbiology · 2023Article
- Advancements in understanding the molecular and immune mechanisms ofFrontiers in microbiology · 2023Review
- Severe acute hepatitis in children: Proposal to investigate Bartonella henselae with a multistep platform.PLoS neglected tropical diseases · 2022Article
- Occurrence and bacterial loads of Bartonella and haemotropic Mycoplasma species in privately owned cats and dogs and their fleas from East and Southeast Asia.Zoonoses and public health · 2022Article
- Cryptogenic hepatitis patients have a higher Bartonella sp.-DNA detection in blood and skin samples than patients with non-viral hepatitis of known cause.PLoS neglected tropical diseases · 2022Article
- Chronic type 2 reaction possibly triggered by an asymptomatic Bartonella henselae infection in a leprosy patient.Revista do Instituto de Medicina Tropical de Sao Paulo · 2022Article
- Two-year history of lymphadenopathy and fever caused by Bartonella henselae in a child.Revista do Instituto de Medicina Tropical de Sao Paulo · 2022Article
- Comparison of Serological and Molecular Assays forPathogens (Basel, Switzerland) · 2021Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bartonella species are blood-borne, re-emerging organisms, capable of causing prolonged infection with diverse disease manifestations, from asymptomatic bacteremia to chronic debilitating disease and death. This pathogen can survive for over a month in stored blood. However, its prevalence among blood donors is unknown, and screening of blood supplies for this pathogen is not routinely performed. We investigated Bartonella spp. prevalence in 500 blood donors from Campinas, Brazil, based on a cross-sectional design. Blood samples were inoculated into an enrichment liquid growth medium and sub-inoculated onto blood agar. Liquid culture samples and Gram-negative isolates were tested using a genus specific ITS PCR with amplicons sequenced for species identification. Bartonella henselae and Bartonella quintana antibodies were assayed by indirect immunofluorescence. B. henselae was isolated from six donors (1.2%). Sixteen donors (3.2%) were Bartonella-PCR positive after culture in liquid or on solid media, with 15 donors infected with B. henselae and one donor infected with Bartonella clarridgeiae. Antibodies against B. henselae or B. quintana were found in 16% and 32% of 500 blood donors, respectively. Serology was not associated with infection, with only three of 16 Bartonella-infected subjects seropositive for B. henselae or B. quintana. Bartonella DNA was present in the bloodstream of approximately one out of 30 donors from a major blood bank in South America. Negative serology does not rule out Bartonella spp. infection in healthy subjects. Using a combination of liquid and solid cultures, PCR, and DNA sequencing, this study documents for the first time that Bartonella spp. bacteremia occurs in asymptomatic blood donors. Our findings support further evaluation of Bartonella spp. transmission which can occur through blood transfusions.
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