ArticleInternational journal of molecular sciences2015
The potential of minor ginsenosides isolated from the leaves of Panax ginseng as inhibitors of melanogenesis.
Article in International journal of molecular sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Application of probiotic bacteria in ginsenoside bioconversion and enhancing its health-promoting benefits: a review.Food science and biotechnology · 2025Review
- In Vitro and In Vivo Antimelanogenesis Effects of Leaf Essential Oil fromPharmaceutics · 2023Article
- Plants as Modulators of Melanogenesis: Role of Extracts, Pure Compounds and Patented Compositions in Therapy of Pigmentation Disorders.International journal of molecular sciences · 2022Review
- Comparison between the Biological Active Compounds in Plants with Adaptogenic Properties (Plants (Basel, Switzerland) · 2021Review
- Antimelanogenesis Effects of Leaf Extract and Phytochemicals from Ceylon Olive (Pharmaceutics · 2021Article
- Low Molecular Weight Oligosaccharide fromEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Ginsenosides analysis of New Zealand-grown forestJournal of ginseng research · 2020Article
- Anti-inflammatory and Cytotoxic Triterpenes from the Rot Roots of Panax notoginseng.Natural products and bioprospecting · 2019Article
- Isolation and Quantification of Ginsenoside Rh23, a New Anti-Melanogenic Compound from the Leaves of Panax ginseng.Molecules (Basel, Switzerland) · 2018Article
- Melanogenesis inhibition activity of floralginsenoside A fromJournal of ginseng research · 2017Article
- Liquid Chromatography-Mass Spectrometry-Based Rapid Secondary-Metabolite Profiling of Marine Pseudoalteromonas sp. M2.Marine drugs · 2016Article
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Authors and funding
9 authors.
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Abstract
Three minor ginsenosides, namely, ginsenoside Rh6 (1), vina-ginsenoside R4 (2) and vina-ginsenoside R13 (3), were isolated from the leaves of hydroponic Panax ginseng. The chemical structures were determined based on spectroscopic methods, including fast atom bombardment mass spectroscopy (FAB-MS), 1D-nuclear magnetic resonance (NMR), 2D-NMR, and, infrared (IR) spectroscopy. The melanogenic inhibitory activity of compounds 1, 2 and 3 was 23.9%, 27.8% and 35.2%, respectively, at a concentration of 80 µM. Likewise, the three compounds showed inhibitory activity on body pigmentation on a zebrafish model, which is commonly used as a model for biomedical or cosmetic research. These results from in vitro and in vivo systems suggest that the three aforementioned compounds isolated from Panax ginseng may have potential as new skin whitening compounds.
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