Evidence map›Paper›PMID 25590219›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2015

Prone positioning decreases cardiac output and increases systemic vascular resistance in neonates.

M Ma, S Noori, J-M Maarek, D P Holschneider, E H Rubinstein, I Seri

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03086473 (A Randomized, Placebo-controlled Trial of Early Caffeine in Preterm Neonates), which is not on this map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03086473 phase4unknown statusnot on this mapstarted 2017, after this paper: background citation

A Randomized, Placebo-controlled Trial of Early Caffeine in Preterm Neonates

TypeinterventionalSponsorJennifer ShepherdRan2017 to 2022Enrolled24ConditionsBPD - Bronchopulmonary Dysplasia, Apnea of Prematurity, Hemodynamic Instability, IntubationArmsCaffeine Citrate, Placebo (Normal Saline)
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Trial
  4. Neonatal reference values and nomograms of systemic vascular resistances estimated with electrical cardiometry.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Article
  5. Observational
  6. Decreased cardiac output: an integrative review.Revista brasileira de enfermagem · 2023
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Cardiac output decreases and systemic vascular resistance increases in newborns placed in the left-lateral position.Journal of perinatology : official journal of the California Perinatal Association · 2017
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

M Ma1] Division of Neonatology and the Center for Fetal and Neonatal Medicine, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, USA [2] The LAC+USC Medical Center, Los Angeles, CA, USA [3] Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
S Noori1] Division of Neonatology and the Center for Fetal and Neonatal Medicine, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, USA [2] The LAC+USC Medical Center, Los Angeles, CA, USA [3] Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
J-M MaarekDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA,USA.
D P Holschneider1] Department of Biomedical Engineering, University of Southern California, Los Angeles, CA,USA [2] Department of Psychiatry and Behavioral Science, University of Southern California, Los Angeles, CA, USA.
E H RubinsteinDepartment of Anesthesiology, University of California Los Angeles, Los Angeles, CA,USA.
I Seri1] Division of Neonatology and the Center for Fetal and Neonatal Medicine, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, USA [2] The LAC+USC Medical Center, Los Angeles, CA, USA [3] Keck School of Medicine, University of Southern California, Los Angeles, CA, USA [4] Sidra Neonatology Center of Excellence, Department of Pediatrics, Sidra Medical and Research Center, Doha, Qatar.
Children's Hospital of Los Angeles · USUniversity of Southern California · USLAC+USC Medical Center · USUniversity of California, Los Angeles · US

Funding

Monitoring of Cardiovascular Function in Infants By Transcutaneous Dye DilutionR01HL103765 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HOLSCHNEIDER, DANIEL PHILIPP, MAAREK, JEAN-MICHEL · 2010 to 2013
$1.6M
NHLBI NIH HHS 1R01HL103765-01
6 · The paper itself

Abstract

objectiveTo evaluate the cardiovascular response to short-term prone positioning in neonates. STUDY

designIn this prospective study, we continuously monitored heart rate (HR), stroke volume (SV) and cardiac output (CO) by electrical velocimetry in hemodynamically stable neonates in each of the following positions for 10 min: supine, prone and back-to-supine position. Skin blood flow (SBF) was also continuously assessed on the forehead or foot using Laser Doppler technology. Systemic vascular resistance (SVR) index was calculated as mean blood pressure (BP)/CO. Data were analyzed using repeated measures analysis of variance.

resultsThirty neonates (gestational age: 35±4 weeks; postmenstrual age: 36±3 weeks) were enrolled. HR did not change in response to positioning. However, in prone position, SV, CO and SBF decreased and SVR index increased from 1.5±0.3 to 1.3±0.3 ml kg(-1) (mean ±s.d., P<0.01), 206±44 to 180±41 ml kg(-1) min(-1) (P<0.01), 0.54±0.30 to 0.44±0.29 perfusion units (P<0.01) and 0.25±0.06 to 0.30±0.07 mm Hg ml(-1) kg(-1) min(-1) (P<0.01), respectively. After placing the infants back-to-supine position, SV, CO, SBF and SVR index returned to baseline. The above pattern of cardiovascular changes was consistent in vast majority of the studied neonates.

conclusionsShort-term prone positioning is associated with decreased SV, CO and SBF and increased calculated SVR index.

Indexed as

Cardiac OutputFemaleHeart RateHumansInfant, NewbornLaser-Doppler FlowmetryMaleProne PositionProspective StudiesSkinStroke VolumeSupine PositionVascular Resistance

Identifiers

PMID25590219
OpenAlexW2043136903

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.