Evidence map›Paper›PMID 25590043›Full record

ArticleAnnals of clinical and translational neurology2014

Spinal cord atrophy in early Huntington's disease.

Mark Mühlau, Christina Engl, Christine C Boucard, Paul Schmidt, Viola Biberacher, Isabel Görsch, Christian Sorg, Afra Wohlschläger, Claus Zimmer, Bernhard Hemmer and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical and translational neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Pain in Huntington's disease and its potential mechanisms.Frontiers in aging neuroscience · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Mark MühlauDepartment of Neurology, Klinikum rechts der Isar, Technische Universität München Munich, Germany ; TUM-Neuroimaging Center, Klinikum rechts der Isar, Technische Universität München Munich, Germany ; Munich Cluster for Systems Neurology (SyNergy) Munich, Germany.
Christina EnglDepartment of Neurology, Klinikum rechts der Isar, Technische Universität München Munich, Germany ; TUM-Neuroimaging Center, Klinikum rechts der Isar, Technische Universität München Munich, Germany.
Christine C BoucardDepartment of Neurology, Klinikum rechts der Isar, Technische Universität München Munich, Germany ; TUM-Neuroimaging Center, Klinikum rechts der Isar, Technische Universität München Munich, Germany.
Paul SchmidtDepartment of Neurology, Klinikum rechts der Isar, Technische Universität München Munich, Germany ; TUM-Neuroimaging Center, Klinikum rechts der Isar, Technische Universität München Munich, Germany ; Department of Statistics, Ludwig-Maximilians-University München Munich, Germany.
Viola BiberacherDepartment of Neurology, Klinikum rechts der Isar, Technische Universität München Munich, Germany ; TUM-Neuroimaging Center, Klinikum rechts der Isar, Technische Universität München Munich, Germany.
Isabel GörschDepartment of Neurology, Klinikum rechts der Isar, Technische Universität München Munich, Germany ; Department of Ophthalmology, University Hospital Hamburg Hamburg, Germany.
Christian SorgTUM-Neuroimaging Center, Klinikum rechts der Isar, Technische Universität München Munich, Germany ; Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München Munich, Germany ; Department of Psychiatry, Klinikum rechts der Isar, Technische Universität München Munich, 81675, Germany.
Afra WohlschlägerTUM-Neuroimaging Center, Klinikum rechts der Isar, Technische Universität München Munich, Germany ; Department of Neuroradiology, Klinikum rechts der Isar, Technische Universität München Munich, Germany.
Claus ZimmerDepartment of Neuroradiology, Klinikum rechts der Isar, Technische Universität München Munich, Germany.
Bernhard HemmerDepartment of Neurology, Klinikum rechts der Isar, Technische Universität München Munich, Germany ; Munich Cluster for Systems Neurology (SyNergy) Munich, Germany.
Adolph WeindlDepartment of Neurology, Klinikum rechts der Isar, Technische Universität München Munich, Germany.
Klinikum rechts der Isar · DETechnical University of Munich · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite evidence for spinal cord involvement, it remains unclear whether spinal cord atrophy exists in early Huntington's disease. We studied magnetic resonance images, covering both brain and upper cervical cord, in two cohorts of Huntington's patients and in one cohort of Alzheimer's patients. All cohorts included healthy controls comparable with regard to age and gender. We found significant spinal cord atrophy in both cohorts of Huntington's patients but not in the cohort of Alzheimer's patients. Furthermore, spinal cord atrophy correlated with motor symptoms indicating that spinal cord atrophy occurs in the clinical stages and does not result from abnormal development.

Identifiers

PMID25590043
PMCPMC4292748
OpenAlexW1983550326

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.