Evidence map›Paper›PMID 25589953›Full record

ArticleBiomaterials science2015

MMP9-sensitive polymers mediate environmentally-responsive bivalirudin release and thrombin inhibition.

D S Chu, D L Sellers, M J Bocek, A E Fischedick, P J Horner, S H Pun

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 22 citations in OpenAlex.

  1. Drug delivery to the central nervous system.Nature reviews. Materials · 2022
    Article
  2. Review
  3. Article
  4. Regenerative Therapies for Spinal Cord Injury.Tissue engineering. Part B, Reviews · 2019
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

D S ChuDepartment of Bioengineering and Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA 98195, USA.
D L SellersDepartment of Neurological Surgery and Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195, USA.
M J BocekDepartment of Bioengineering and Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA 98195, USA.
A E FischedickDepartment of Neurological Surgery and Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195, USA.
P J HornerDepartment of Neurological Surgery and Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195, USA.
S H PunDepartment of Bioengineering and Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA 98195, USA.
Neurological Surgery · USUniversity of Washington · USSeattle University · US

Funding

Ultrasound-aided gene transfer to direct cortical neurogenesis after brain injuryR01NS064404 · NINDS · UNIVERSITY OF WASHINGTON · PI HORNER, PHILIP J, PUN, SUZIE H. · 2009 to 2018
$3.5M
Nanotechnology and Physical Science Training Program in Cancer ResearchT32CA138312 · NCI · UNIVERSITY OF WASHINGTON · PI ZHANG, MIQIN · 2009 to 2013
$1.5M
NCI NIH HHS T32 CA138312NINDS NIH HHS 1R01NS064404NINDS NIH HHS R01 NS064404
6 · The paper itself

Abstract

MMP9-responsive bivalirudin-HPMA copolymers were synthesized for direct, local administration in rat spinal cord contusion injury models. Polymer-conjugated bivalirudin peptides maintained activity while demonstrating enzyme-mediated release upon MMP9 exposure and prolonged release from hyaluronic acid/methylcellulose (HAMC) hydrogels compared to free bivalirudin peptide. Localized administration of bivalirudin copolymers in vivo at the site of rat spinal cord injury decreased cellular proliferation and astrogliosis, suggesting the bivalirudin copolymer and HAMC hydrogel system are a promising therapeutic intervention for reducing immediate inflammatory responses and long term scarring.

Indexed as

AnimalsHirudinsHyaluronic AcidHydrogel, Polyethylene Glycol DimethacrylateHydrogelsMatrix Metalloproteinase 9MethylcellulosePeptide FragmentsRatsRecombinant ProteinsSpinal Cord InjuriesThrombinbivalirudinHirudinsHyaluronic AcidHydrogel, Polyethylene Glycol DimethacrylateHydrogelsMatrix Metalloproteinase 9MethylcellulosePeptide FragmentsRecombinant ProteinsThrombin

Identifiers

PMID25589953
PMCPMC4289632
OpenAlexW2151406409

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.