ArticleInternational journal of medical sciences2015
Liver function parameters in hip fracture patients: relations to age, adipokines, comorbidities and outcomes.
Article in International journal of medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Age- and sex- related patterns in hematobiochemical and anthropometric parameters of Macaca monkeys.GeroScience · 2026Article
- The Effect of Bone Minerals Density on Mortality of Elderly Patients Applying with a Proximal Fracture of the Femur.Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca · 2026Article
- The Akcaalan Mortality Score: A Novel Mortality Score to Predict 3-Year Mortality for Elderly Hip Fractures.Journal of clinical medicine · 2025Article
- Prediction of Osteoporotic Hip Fracture Outcome: Comparative Accuracy of 27 Immune-Inflammatory-Metabolic Markers and Related Conceptual Issues.Journal of clinical medicine · 2024Article
- Multiplexed bacterial pathogen detection and clinical characteristics of orthopedic infection in hospitalized patients.Frontiers in cellular and infection microbiology · 2024Article
- Is Follow-up Co-Morbidity Assessment via Laboratory Investigations in Older High Energy Trauma Patients Justified? - A Prospective-Retrospective Study.Malaysian orthopaedic journal · 2023Article
- Comparison of Prognostic Value of 10 Biochemical Indices at Admission for Prediction Postoperative Myocardial Injury and Hospital Mortality in Patients with Osteoporotic Hip Fracture.Journal of clinical medicine · 2022Article
- Elevated gamma-glutamyl transpeptidase level is associated with an increased risk of hip fracture in postmenopausal women.Scientific reports · 2022Article
- Article
- Correlation of serum PTH level and fracture healing speed in elderly patients with hip fracture.Journal of orthopaedic surgery and research · 2019Article
- Bone Turnover Status: Classification Model and Clinical Implications.International journal of medical sciences · 2018Article
- A Comprehensive Analysis of the Causes and Predictors of 30-Day Mortality Following Hip Fracture Surgery.Clinics in orthopedic surgery · 2017Article
- Lower serum P1NP/βCTX ratio and hypoalbuminemia are independently associated with osteoporotic nonvertebral fractures in older adults.Clinical interventions in aging · 2017Observational
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo asses liver markers in older patients with hip fracture (HF) in relation to age, comorbidities, metabolic characteristics and short-term outcomes.
methodsIn 294 patients with HF (mean age 82.0±7.9 years, 72.1% women) serum alanine aminotransferase (ALT), gammaglutamyltransferase (GGT), alkaline phosphatase (ALP), albumin, bilirubin, 25(OH)vitaminD, PTH, calcium, phosphate, magnesium, adiponectin, leptin, resistin, thyroid function and cardiac troponin I were measured.
resultsElevated ALT, GGT, ALP or bilirubin levels on admission were observed in 1.7%-9.9% of patients. With age GGT, ALT and leptin decrease, while PTH and adiponectin concentrations increase. Higher GGT (>30 U/L, median level) was associated with coronary artery disease (CAD), diabetes mellitus (DM), and alcohol overuse; lower ALT (≤20 U/L, median level) with dementia; total bilirubin>20 μmol/L with CAD and alcohol overuse; and albumin>33 g/L with CAD. Multivariate adjusted regression analyses revealed ALT, ALP, adiponectin, alcohol overuse and DM as independent and significant determinants of GGT (as continuous or categorical variable); GGT for each other liver marker; and PTH for adiponectin. The risk of prolonged hospital stay (>20 days) was about two times higher in patients with GGT>30 U/L or adiponectin>17.14 ng/L (median level) and 4.7 times higher if both conditions coexisted. The risk of in-hospital death was 3 times higher if albumin was <33 g/L.
conclusionsIn older HF patients liver markers even within the normal range are associated with age-related disorders and outcomes. Adiponectin (but not 25(OH)vitaminD, PTH, leptin or resistin) is an independent contributor to higher GGT. Serum GGT and albumin predict prolonged hospital stay and in-hospital death, respectively. A unifying hypothesis of the findings presented.
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