ArticleThe Journal of biological chemistry2015
β-Spectrin regulates the hippo signaling pathway and modulates the basal actin network.
Article in The Journal of biological chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 69 citations in OpenAlex.
- A Synergy between Genetics and Biochemistry Unravels the Molecular Architecture of the Hippo Signaling Pathway.Cold Spring Harbor perspectives in biology · 2026Article
- Mechanobiology of the Hippo-YAP Signaling Network.Cold Spring Harbor perspectives in biology · 2026Article
- Targeting the Hippo pathway in cancer.Nature reviews. Drug discovery · 2025Review
- RhoGEF2 overexpression induces cell competition dependent on Ptp10D, Crumbs and the Hippo signaling pathway.Journal of cell science · 2025Article
- Dehydrocorydaline maintains the vascular smooth muscle cell contractile phenotype by upregulating Spta1.Acta pharmacologica Sinica · 2025Article
- Competition between myosin II and βeLife · 2023Article
- The role of Hippo pathway in ovarian development.Frontiers in physiology · 2023Review
- Hippo signaling in cardiac fibroblasts during development, tissue repair, and fibrosis.Current topics in developmental biology · 2022Review
- Loss of SPTBN1 Suppresses Autophagy Via SETD7-mediated YAP Methylation in Hepatocellular Carcinoma Initiation and Development.Cellular and molecular gastroenterology and hepatology · 2022Article
- β2SP/TET2 complex regulates gene 5hmC modification after cerebral ischemia.Journal of cellular and molecular medicine · 2021Article
- Crumbs and the apical spectrin cytoskeleton regulate R8 cell fate in the Drosophila eye.PLoS genetics · 2021Article
- The Hippo pathway: Horizons for innovative treatments of peripheral nerve diseases.Journal of the peripheral nervous system : JPNS · 2021Review
- Calcium, an Emerging Intracellular Messenger for the Hippo Pathway Regulation.Frontiers in cell and developmental biology · 2021Review
- Mechanoregulation of YAP and TAZ in Cellular Homeostasis and Disease Progression.Frontiers in cell and developmental biology · 2021Review
- An overview of signaling pathways regulating YAP/TAZ activity.Cellular and molecular life sciences : CMLS · 2021Review
- A Fresh Look at the Structure, Regulation, and Functions of Fodrin.Molecular and cellular biology · 2020Review
- βH-spectrin is required for ratcheting apical pulsatile constrictions during tissue invagination.EMBO reports · 2020Article
- Spectrin couples cell shape, cortical tension, and Hippo signaling in retinal epithelial morphogenesis.The Journal of cell biology · 2020Article
- A Gene Expression Screen inG3 (Bethesda, Md.) · 2019Article
- Role of Hippo Pathway-YAP/TAZ Signaling in Angiogenesis.Frontiers in cell and developmental biology · 2019Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Emerging evidence suggests functional regulation of the Hippo pathway by the actin cytoskeleton, although the detailed molecular mechanism remains incomplete. In a genetic screen, we identified a requirement for β-Spectrin in the posterior follicle cells for the oocyte repolarization process during Drosophila mid-oogenesis. β-spectrin mutations lead to loss of Hippo signaling activity in the follicle cells. A similar reduction of Hippo signaling activity was observed after β-Spectrin knockdown in mammalian cells. We further demonstrated that β-spectrin mutations disrupt the basal actin network in follicle cells. The abnormal stress fiber-like actin structure on the basal side of follicle cells provides a likely link between the β-spectrin mutations and the loss of the Hippo signaling activity phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.