ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Cholinergic basal forebrain structure influences the reconfiguration of white matter connections to support residual memory in mild cognitive impairment.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- Cholinergic basal forebrain modulation of glymphatic function: implications for depression.Translational psychiatry · 2026Article
- TACR3 variant confers resilience to aging and Alzheimer's disease.medRxiv : the preprint server for health sciences · 2026Article
- The cholinergic basal forebrain and its role in neurodegeneration.Journal of neuropathology and experimental neurology · 2025Review
- A review of brain regions and associated post-concussion symptoms.Frontiers in neurology · 2023Review
- Characterization of diffusion magnetic resonance imaging revealing relationships between white matter disconnection and behavioral disturbances in mild cognitive impairment: a systematic review.Frontiers in neuroscience · 2023Review
- The fornix supports episodic memory during childhood.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Cholinergic neurotransmitter system: a potential marker for post-stroke cognitive recovery.Brain : a journal of neurology · 2022Article
- Cholinergic and hippocampal systems facilitate cross-domain cognitive recovery after stroke.Brain : a journal of neurology · 2022Article
- The role of the medial prefrontal cortex in cognition, ageing and dementia.Brain communications · 2021Review
- Cholinergic Basal Forebrain Volumes Predict Gait Decline in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2021Article
- Effects of Cigarette Smoking on Resting-State Functional Connectivity of the Nucleus Basalis of Meynert in Mild Cognitive Impairment.Frontiers in aging neuroscience · 2021Article
- Dissecting the Fornix in Basic Memory Processes and Neuropsychiatric Disease: A Review.Brain connectivity · 2020Review
- Basal forebrain volume reliably predicts the cortical spread of Alzheimer's degeneration.Brain : a journal of neurology · 2020Article
- Early Segmental White Matter Fascicle Microstructural Damage Predicts the Corresponding Cognitive Domain Impairment in Cerebral Small Vessel Disease Patients by Automated Fiber Quantification.Frontiers in aging neuroscience · 2020Article
- Rescuing the attentional performance of rats with cholinergic losses by the M1 positive allosteric modulator TAK-071.Psychopharmacology · 2020Article
- Article
- The role of artificial intelligence and machine learning in harmonization of high-resolution post-mortem MRI (virtopsy) with respect to brain microstructure.Brain informatics · 2019Article
- The corticotopic organization of the human basal forebrain as revealed by regionally selective functional connectivity profiles.Human brain mapping · 2019Article
- APOE-ε4 risk variant for Alzheimer's disease modifies the association between cognitive performance and cerebral morphology in healthy middle-aged individuals.NeuroImage. Clinical · 2019Article
- The cingulum bundle: Anatomy, function, and dysfunction.Neuroscience and biobehavioral reviews · 2018Review
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
The fornix and hippocampus are critical to recollection in the healthy human brain. Fornix degeneration is a feature of aging and Alzheimer's disease. In the presence of fornix damage in mild cognitive impairment (MCI), a recognized prodrome of Alzheimer's disease, recall shows greater dependence on other tracts, notably the parahippocampal cingulum (PHC). The current aims were to determine whether this shift is adaptive and to probe its relationship to cholinergic signaling, which is also compromised in Alzheimer's disease. Twenty-five human participants with MCI and 20 matched healthy volunteers underwent diffusion MRI, behavioral assessment, and volumetric measurement of the basal forebrain. In a regression model for recall, there was a significant group × fornix interaction, indicating that the association between recall and fornix structure was weaker in patients. The opposite trend was present for the left PHC. To further investigate this pattern, two regression models were generated to account for recall performance: one based on fornix microstructure and the other on both fornix and left PHC. The realignment to PHC was positively correlated with free recall but not non-memory measures, implying a reconfiguration that is beneficial to residual memory. There was a positive relationship between realignment to PHC and basal forebrain gray matter volume despite this region demonstrating atrophy at a group level, i.e., the cognitive realignment to left PHC was most apparent when cholinergic areas were relatively spared. Therefore, cholinergic systems appear to enable adaptation to injury even as they degenerate, which has implications for functional restoration.
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