ArticleJournal of neurophysiology2015
Comparative diffusion tractography of corticostriatal motor pathways reveals differences between humans and macaques.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Accurate localization and coactivation profiles of the frontal eye field and inferior frontal junction: an ALE and MACM fMRI meta-analysis.Brain structure & function · 2023Pooled it
- A supramodal role of the basal ganglia in memory and motor inhibition: Meta-analytic evidence.Neuropsychologia · 2018Pooled it
- Bilateral intermittent theta burst stimulation over the primary motor cortex improves motor and affective symptoms via thalamic network reintegration in mid-stage Parkinson's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Trial
- Putaminal-cortical circuits predict response of bilateral deep brain stimulation of the subthalamic nucleus in the primary Meige syndrome after 5 years.Brain communications · 2025Article
- Mapping cross-species connectome atlas of human and macaque striatum.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Functional parcellation of human and macaque striatum reveals human-specific connectivity in the dorsal caudate.NeuroImage · 2021Article
- Functional Connectivity Changes of Key Regions for Motor Initiation in Parkinson's Disease.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Hypoxia-Ischemia and Hypothermia Independently and Interactively Affect Neuronal Pathology in Neonatal Piglets with Short-Term Recovery.Developmental neuroscience · 2019Article
- Causal Role of Neural Signals Transmitted From the Frontal Eye Field to the Superior Colliculus in Saccade Generation.Frontiers in neural circuits · 2018Review
- Combining diffusion magnetic resonance tractography with stereology highlights increased cross-cortical integration in primates.The Journal of comparative neurology · 2017Article
- Speed of saccade execution and inhibition associated with fractional anisotropy in distinct fronto-frontal and fronto-striatal white matter pathways.Human brain mapping · 2016Article
- Negative childhood experiences alter a prefrontal-insular-motor cortical network in healthy adults: A preliminary multimodal rsfMRI-fMRI-MRS-dMRI study.Human brain mapping · 2015Article
- Parallel basal ganglia circuits for voluntary and automatic behaviour to reach rewards.Brain : a journal of neurology · 2015Review
- Changes in Effective Connectivity of the Superior Parietal Lobe during Inhibition and Redirection of Eye Movements.Journal of experimental neuroscience · 2015Article
- What makes a frontal area of primate brain the frontal eye field?Frontiers in integrative neuroscience · 2015Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The primate corticobasal ganglia circuits are understood to be segregated into parallel anatomically and functionally distinct loops. Anatomical and physiological studies in macaque monkeys are summarized as showing that an oculomotor loop begins with projections from the frontal eye fields (FEF) to the caudate nucleus, and a motor loop begins with projections from the primary motor cortex (M1) to the putamen. However, recent functional and structural neuroimaging studies of the human corticostriatal system report evidence inconsistent with this organization. To obtain conclusive evidence, we directly compared the pattern of connectivity between cortical motor areas and the striatum in humans and macaques in vivo using probabilistic diffusion tractography. In macaques we found that FEF is connected with the head of the caudate and anterior putamen, and M1 is connected with more posterior sections of the caudate and putamen, corroborating neuroanatomical tract tracing findings. However, in humans FEF and M1 are connected to largely overlapping portions of posterior putamen and only a small portion of the caudate. These results demonstrate that the corticobasal connectivity for the oculomotor and primary motor loop is not entirely segregated for primates at a macroscopic level and that the description of the anatomical connectivity of corticostriatal motor systems in humans does not parallel that of macaques, perhaps because of an expansion of prefrontal projections to striatum in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.