SynthesisJournal of the American Heart Association2015
Resting heart rate and risk of incident heart failure: three prospective cohort studies and a systematic meta-analysis.
Synthesis in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Brazilian Guideline for Exercise Test in the Adult Population - 2024.Arquivos brasileiros de cardiologia · 2024Guideline
- Association between resting heart rate and coronary artery disease, stroke, sudden death and noncardiovascular diseases: a meta-analysis.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2016Pooled it
- Atrial Fibrillation and Declining Physical Performance in Older Adults: The Health, Aging, and Body Composition Study.Circulation. Arrhythmia and electrophysiology · 2016Trial
- Resting Heart Rate Association with Cardiovascular Morbidity and Mortality and All-Cause Mortality According to Cluster of Cardiovascular Risk Factors-A Prospective Cohort Study with More than 20 Years of Follow-Up.Journal of clinical medicine · 2026Article
- cAMP-Activated EPAC Signaling Is an Integral Component of Cardiac Pacemaker Cell Automaticity.Circulation. Arrhythmia and electrophysiology · 2026Article
- Resting Heart Rate and Associations With Clinical Measures From the Project Baseline Health Study: Observational Study.Journal of medical Internet research · 2024Observational
- Home Pulse Rate Before and During Antihypertensive Treatment and Mortality Risk in Hypertensive Patients: A Post Hoc Analysis of the HOMED-BP Study.Journal of the American Heart Association · 2024Article
- Accuracy of smartwatches for the remote assessment of exercise capacity.Scientific reports · 2024Article
- Minimum heart rate and mortality after cardiac surgery: retrospective analysis of the Multi-parameter Intelligent Monitoring in Intensive Care (MIMIC-III) database.Scientific reports · 2023Article
- Effect of hypertriglyceridemia on left ventricular global longitudinal strain in patients with coronary heart disease in Jilin Province, China: a cross-sectional study.Frontiers in cardiovascular medicine · 2023Article
- Heart rate variability during auricular acupressure at the left sympathetic point on healthy volunteers: a pilot study.Frontiers in neuroscience · 2023Article
- Low Heart Rate Is Associated with Cerebral Pulsatility after TIA or Minor Stroke.Annals of neurology · 2022Article
- Resting heart rate and risk of left and right heart failure in 0.5 million Chinese adults.Open heart · 2022Article
- Regional differences in office and self-measured home heart rates in Asian hypertensive patients: AsiaBP@Home study.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Minimum heart rate and mortality in critically ill myocardial infarction patients: an analysis of the MIMIC-III database.Annals of translational medicine · 2021Article
- Association of Night-Time Heart Rate With Ventricular Tachyarrhythmias, Appropriate and Inappropriate Implantable Cardioverter-Defibrillator Shocks.Frontiers in cardiovascular medicine · 2021Article
- Age, aging and physiological dysregulation in safety-critical work: a retrospective longitudinal study of helicopter emergency medical services pilots.International archives of occupational and environmental health · 2020Article
- Link Between Elevated Long-Term Resting Heart Rate Variability and Pulse Pressure Variability for All-Cause Mortality.Journal of the American Heart Association · 2020Article
- The Association Between Heart Rate and Glycemic Status in the National Health and Nutrition Examination Surveys.The Journal of clinical endocrinology and metabolism · 2020Article
- Resting heart rate and incidence of venous thromboembolism.Research and practice in thrombosis and haemostasis · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 9 institutions in 3 countries.
Funding
Abstract
backgroundThe relationship between resting heart rate (RHR) and incident heart failure (HF) has been questioned. METHODS AND
resultsRHR was assessed at baseline in 7073 participants in 3 prospective cohorts (Cardiovascular Health Study, Health ABC study and Kuopio Ischemic Heart Disease Study) that recorded 1189 incident HF outcomes during 92 702 person-years of follow-up. Mean age of participants was 67 (9.9) years and mean RHR was 64.6 (11.1) bpm. Baseline RHR correlated (P<0.001) positively with body mass index (r=0.10), fasting glucose (r=0.18), and C-reactive protein (r=0.20); and inversely with serum creatinine (r=-0.05) and albumin (r=-0.05). Baseline RHR was non-linearly associated with HF risk. The age and sex-adjusted hazard ratio for HF comparing the top (>72 bpm) versus the bottom (<57 bpm) quartile of baseline RHR was 1.48 (95% confidence interval [CI] 1.26 to 1.74) and was modestly attenuated (1.30, 95% CI 1.10 to 1.53) with further adjustment for body mass index, history of diabetes, hypertension, smoking status, serum creatinine, and left ventricular hypertrophy. These findings remained consistent in analyses accounting for incident coronary heart disease, excluding individuals with prior cardiovascular events, or those taking beta-blockers; and in subgroups defined by several individual participant characteristics. In a pooled random effects meta-analysis of 7 population-based studies (43 051 participants and 3476 HF events), the overall hazard ratio comparing top versus bottom fourth of RHR was 1.40 (95% CI: 1.19 to 1.64).
conclusionsThere is a non-linear association between RHR and incident HF. Further research is needed to understand the physiologic foundations of this association.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.