ArticleMolecular human reproduction2015
Activation of decidual invariant natural killer T cells promotes lipopolysaccharide-induced preterm birth.
Article in Molecular human reproduction, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Second-trimester amniotic fluid proteins changes in subsequent spontaneous preterm birth.Acta obstetricia et gynecologica Scandinavica · 2023Trial
- The landscape of decidual immune cells at the maternal-fetal interface in parturition and preterm birth.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- Mechanisms of Tolerance Induction in Liver Transplantation: Lessons Learned from Fetomaternal Tolerance, Autoimmunity and Tumor Immunity.International journal of molecular sciences · 2024Review
- Role of Transcription Factors in the Management of Preterm Birth: Impact on Future Treatment Strategies.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- Tissue-resident immunity in the female and male reproductive tract.Seminars in immunopathology · 2022Review
- The Role of Type I and Type II NKT Cells in Materno-Fetal Immunity.Biomedicines · 2021Review
- IL-27 Mediates Pro-Inflammatory EffectsFrontiers in immunology · 2021Article
- Maternal and fetal T cells in term pregnancy and preterm labor.Cellular & molecular immunology · 2020Review
- High Frequency of Gamma Interferon-Producing PLZFJournal of virology · 2020Article
- Immunobiology of Acute Chorioamnionitis.Frontiers in immunology · 2020Review
- The Role of Danger Associated Molecular Patterns in Human Fetal Membrane Weakening.Frontiers in physiology · 2020Review
- The role of maternal T cell and macrophage activation in preterm birth: Cause or consequence?Placenta · 2019Review
- Chronic Gestational Inflammation: Transfer of Maternal Adaptation over Two Generations of Progeny.Mediators of inflammation · 2019Article
- Immune cell and transcriptomic analysis of the human decidua in term and preterm parturition.Molecular human reproduction · 2017Article
- In vivo activation of invariant natural killer T cells induces systemic and local alterations in T-cell subsets prior to preterm birth.Clinical and experimental immunology · 2017Article
- Article
- Mapping out p38MAPK.American journal of reproductive immunology (New York, N.Y. : 1989) · 2017Review
- Synthetic PreImplantation Factor (PIF) prevents fetal loss by modulating LPS induced inflammatory response.PloS one · 2017Article
- Invariant NKT Cell Activation Induces Late Preterm Birth That Is Attenuated by Rosiglitazone.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Immune cells and preterm labour: do invariant NKT cells hold the key?Molecular human reproduction · 2015Article
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Invariant natural killer T (iNKT) cells are crucial for host defense against a variety of microbial pathogens, but the underlying mechanisms of iNKT cells activation by microbes are not fully explained. In this study, we investigated the molecular mechanisms of iNKT cell activation in lipopolysaccharide (LPS)-stimulated preterm birth using an adoptive transfer system and diverse neutralizing antibodies (Abs) and inhibitors. We found that adoptive transfer of decidual iNKT cells to LPS-stimulated iNKT cell deficient Jα18(-/-) mice that lack invariant Vα14Jα281T cell receptor (TCR) expression significantly decreased the time to delivery and increased the percentage of decidual iNKT cells. Neutralizing Abs against Toll-like receptor 4 (TLR-4), CD1d, interleukin (IL)-12 and IL-18, and inhibitors blocking the activation of nuclear factor κB (NF-κB), mitogen-activated protein kinase (MAPK) p38 and extracellular signal-regulated kinase (ERK) significantly reduced in vivo percentages of decidual iNKT cells, their intracellular interferon (IFN)-γ production and surface CD69 expression. In vitro, in the presence of the same Abs and inhibitors used as in vivo, decidual iNKT cells co-cultured with LPS-pulsed dendritic cells (DCs) showed significantly decreased extracellular and intracellular IFN-γ secretion and surface CD69 expression. Our data demonstrate that the activation of decidual iNKT cells plays an important role in inflammation-induced preterm birth. Activation of decidual iNKT cells also requires TLR4-mediated NF-κB, MAPK p38 and ERK pathways, the proinflammatory cytokines IL-12 and IL-18, and endogenous glycolipid antigens presented by CD1d.
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