ArticleLab on a chip2015
Continuous-flow sorting of stem cells and differentiation products based on dielectrophoresis.
Article in Lab on a chip, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed.
- Using human 3D organoid models to gain mechanistic insight in motor neuron diseases.Nature reviews. Neuroscience · 2026Review
- Reconfigurable multibeam engineering of Marangoni convection for programmable optofluidic steering.Nature communications · 2026Article
- Integrated DEP presorting and wireless electrode array for high-throughput selective single-cell isolation.Lab on a chip · 2026Article
- Article
- Label-Free Sorting of Human Mesenchymal Stem Cells Using Insulating Dielectrophoresis.Electrophoresis · 2025Article
- Integration of acoustic, optical, and electrical methods in picoliter droplet microfluidics for rare particles enrichment.Communications engineering · 2025Article
- Synergistic potential of stem cells and microfluidics in regenerative medicine.Molecular and cellular biochemistry · 2025Review
- Microfluidic-based electrically driven particle manipulation techniques for biomedical applications.RSC advances · 2025Review
- Deep Learning-Assisted Label-Free Parallel Cell Sorting with Digital Microfluidics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Light-Emitting Diode Array with Optical Linear Detector Enables High-Throughput Differential Single-Cell Dielectrophoretic Analysis.Sensors (Basel, Switzerland) · 2024Article
- Designing Microfluidic-Chip Filtration with Multiple Channel Networks for the Highly Efficient Sorting of Cell Particles.Micromachines · 2024Article
- Effective Boundary Correction for Deterministic Lateral Displacement Microchannels to Improve Cell Separation: A Numerical and Experimental Study.Biosensors · 2024Article
- On-chip dielectrophoretic single-cell manipulation.Microsystems & nanoengineering · 2024Review
- Portable dielectrophoresis for biology: ADEPT facilitates cell trapping, separation, and interactions.Microsystems & nanoengineering · 2024Article
- Microfluidic pumps for cell sorting.Biomicrofluidics · 2023Review
- Quantification of capture efficiency, purity, and single-cell isolation in the recovery of circulating melanoma cells from peripheral blood by dielectrophoresis.Lab on a chip · 2023Article
- Continuous Flow Separation of Red Blood Cells and Platelets in a Y-Microfluidic Channel Device with Saw-Tooth Profile Electrodes via Low Voltage Dielectrophoresis.Current issues in molecular biology · 2023Article
- Implementation of an Integrated Dielectrophoretic and Magnetophoretic Microfluidic Chip for CTC Isolation.Biosensors · 2022Article
- A dielectrophoresis-based microfluidic system having double-sided optimized 3D electrodes for label-free cancer cell separation with preserving cell viability.Scientific reports · 2022Article
- Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
This paper presents a continuous-flow microfluidic device for sorting stem cells and their differentiation progenies. The principle of the device is based on the accumulation of multiple dielectrophoresis (DEP) forces to deflect cells laterally in conjunction with the alternating on/off electric field to manipulate the cell trajectories. The microfluidic device containing a large array of oblique interdigitated electrodes was fabricated using a combination of standard and soft lithography techniques to generate a PDMS-gold electrode construct. Experimental testing with human mesenchymal stem cells (hMSC) and their differentiation progenies (osteoblasts) was carried out at different flow rates, and clear separation of the two populations was achieved. Most of the osteoblasts experiencing stronger DEP forces were deflected laterally and continuously, following zig-zag trajectories, and moved towards the desired collection outlet, whereas most of the hMSCs remained on the original trajectory due to weaker DEP forces. The experimental measurements were characterized and evaluated quantitatively, and consistent performance was demonstrated. Collection efficiency up to 92% and 67% for hMSCs and osteoblasts, respectively, along with purity up to 84% and 87% was obtained. The experimental results established the feasibility of our microfluidic DEP sorting device for continuous, label-free sorting of stem cells and their differentiation progenies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.