ReviewComprehensive Physiology2015
Neural control of the circulation: how sex and age differences interact in humans.
Review in Comprehensive Physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 68 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Adrenergic Blocker Therapy on Cardiac and Striatal Transporter Uptake in Pre-Motor and Symptomatic Parkinson's Disease
The Effect of alpha1- Adrenergic Receptor Antagonist Therapy on Cardiac and Striatal Transporter Uptake in Pre-Motor and Symptomatic Parkinson's Disease: A Follow up Study
Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it, 118 citations in OpenAlex.
- Sex-Specific Differences in Cardiovascular Adaptations and Risks in Elite Athletes: Bridging the Gap in Sports Cardiology.Clinical cardiology · 2024Pooled it
- Oral contraceptives and menstrual cycle influence autonomic reflex function.Physiological reports · 2020Trial
- Daily fatigue-recovery balance monitoring with heart rate variability in well-trained female cyclists on the Tour de France circuit.PloS one · 2019Trial
- Pharmacogenomics of estrogens on changes in carotid artery intima-medial thickness and coronary arterial calcification: Kronos Early Estrogen Prevention Study.Physiological genomics · 2016Trial
- Peripheral chemoreflex inhibition with low-dose dopamine: new insight into mechanisms of extreme apnea.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Trial
- Reversible, Sexually Dimorphic Sympathetic Aging: Distal Axon Withdrawal Shaped by Prepubertal Gonadal Influences.bioRxiv : the preprint server for biology · 2026Article
- Combined androgen excess polycystic ovary syndrome and obesity are associated with elevated beat-to-beat blood pressure variability in adult women.American journal of physiology. Heart and circulatory physiology · 2026Article
- Comparison of Heart Rate Variability Between Sexes: Impact of a Physically Active Lifestyle.International journal of environmental research and public health · 2026Article
- Endogenous and exogenous determinants of sex differences in blood pressure.NPJ cardiovascular health · 2026Review
- Machine Learning Insights into Age-Related Sex Differences in Blood Pressure: Influence of Diabetes and Body Mass Index.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Article
- Longitudinal sex differences in cerebrovascular ageing in older adults: results from the brain in motion study.The Journal of physiology · 2026Article
- Cardiovascular response to altered gravity in healthy adults: Insight from graded tilt testing.Physiological reports · 2026Article
- Does the Menstrual Phase Matter in Vascular Endothelial Responses to Acute Exercise? A Narrative Review of the Literature.Sports (Basel, Switzerland) · 2025Review
- Biological sex influences relationships between cerebral pulsatility and white matter hyperintensities in aging adults.American journal of physiology. Heart and circulatory physiology · 2025Article
- Age and sex differences in blood pressure regulation: A focus on the vascular baroreflex limb.Physiological reports · 2025Article
- Sex-Specific Patterns in Blood Pressure and Vascular Parameters: The MUJER-EVA Project.Journal of cardiovascular development and disease · 2025Article
- Predictive Threshold Value of the Breathing Reserve for the Decline in Cardiorespiratory Fitness Among the Healthy Middle-Aged Population.Journal of cardiovascular development and disease · 2025Article
- Relationship between resting augmentation index and spontaneous cardiac baroreflex sensitivity during handgrip exercise in postmenopausal women.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025Article
- Physiological Effects of Local Theragun™ Application: An Observational Study in Healthy Female Participants.International journal of sports physical therapy · 2025Article
- Revisiting sex as a biological variable in hypertension research.The Journal of clinical investigation · 2024Review
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
The autonomic nervous system is a key regulator of the cardiovascular system. In this review, we focus on how sex and aging influence autonomic regulation of blood pressure in humans in an effort to understand general issues related to the cardiovascular system as a whole. Younger women generally have lower blood pressure and sympathetic activity than younger men. However, both sexes show marked interindividual variability across age groups with significant overlap seen. Additionally, while men across the lifespan show a clear relationship between markers of whole body sympathetic activity and vascular resistance, such a relationship is not seen in young women. In this context, the ability of the sympathetic nerves to evoke vasoconstriction is lower in young women likely as a result of concurrent β2-mediated vasodilation that offsets α-adrenergic vasoconstriction. These differences reflect both central sympatho-inhibitory effects of estrogen and also its influence on peripheral vasodilation at the level of the vascular smooth muscle and endothelium. By contrast postmenopausal women show a clear relationship between markers of whole body sympathetic traffic and vascular resistance, and sympathetic activity rises progressively in both sexes with aging. These major findings in humans are discussed in the context of differences in population-based trends in blood pressure and orthostatic intolerance. The many areas where there is little sex-specific data on how the autonomic nervous system participates in the regulation of the human cardiovascular system are highlighted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.