ReviewComprehensive Physiology2015
Sympathoneural and adrenomedullary responses to mental stress.
Review in Comprehensive Physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed.
- Trial
- Sympathetic neural reactivity to mental stress in humans: test-retest reproducibility.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Trial
- Single-cell transcriptomics provides insights into the stress-immune interplay and informs disease risk.Cell genomics · 2026Article
- Development of a Metagenomics-Guided Personalized Synbiotic Protocol for Children with Autism Spectrum Disorder: An Exploratory Case Series.Nutrients · 2026Article
- Effects of acute high-intensity exercise on heart rate variability following rapid weight loss in elite wrestlers.Scientific reports · 2026Article
- Affective Responsivity and Cardiovascular Stress Reactivity in Depression.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Psychological Stress and Male Infertility: Oxidative Stress as the Common Downstream Pathway.Biomedicines · 2026Review
- Uncovering the metabolic impact of acute psychological stress in young adults.Scientific reports · 2026Observational
- Rumen-host crosstalk: an amplifier of systemic pathology in heat-stressed ruminants.Frontiers in microbiology · 2026Review
- Characteristics of energy metabolism and stress load in elite MOBA E-sports athletes.Frontiers in physiology · 2026Article
- Bridging physiology and psychology: a new framework for teaching homeostasis.Frontiers in physiology · 2026Article
- Peripheral catecholamine systems: an evolutionary perspective.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Review
- Miglustat ameliorates isoproterenol-induced cardiac fibrosis via targeting UGCG.Molecular medicine (Cambridge, Mass.) · 2025Article
- Neuroscience of cancer: unraveling the complex interplay between the nervous system, the tumor and the tumor immune microenvironment.Molecular cancer · 2025Review
- The insular cortex, autonomic asymmetry and cardiovascular control: looking at the right side of stroke.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Review
- Stress Hormones: Unveiling the Role in Accelerated Cellular Senescence.Aging and disease · 2024Review
- Effects of Acute Mental Stress on Choroidal Thickness.Bioengineering (Basel, Switzerland) · 2024Article
- Validity of mental and physical stress models.Neuroscience and biobehavioral reviews · 2024Review
- Differential control of sympathetic outflow to muscle and skin during physical and cognitive stressors.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Article
- Evolutionarily conserved mechanisms regulating stress-induced neutrophil redistribution in fish.Frontiers in immunology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
This concept-based review provides historical perspectives and updates about sympathetic noradrenergic and sympathetic adrenergic responses to mental stress. The topic of this review has incited perennial debate, because of disagreements over definitions, controversial inferences, and limited availability of relevant measurement tools. The discussion begins appropriately with Cannon's "homeostasis" and his pioneering work in the area. This is followed by mental stress as a scientific idea and the relatively new notions of allostasis and allostatic load. Experimental models of mental stress in rodents and humans are discussed, with particular attention to ethical constraints in humans. Sections follow on sympathoneural responses to mental stress, reactivity of catecholamine systems, clinical pathophysiologic states, and the cardiovascular reactivity hypothesis. Future advancement of the field will require integrative approaches and coordinated efforts between physiologists and psychologists on this interdisciplinary topic.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.