Evidence map›Paper›PMID 25589238›Full record

ArticleVirology2015

An expanded taxonomy of hepatitis C virus genotype 6: Characterization of 22 new full-length viral genomes.

Chunhua Li, Eleanor Barnes, Paul N Newton, Yongshui Fu, Manivanh Vongsouvath, Paul Klenerman, Hiroaki Okamoto, Kenji Abe, Oliver G Pybus, Ling Lu

Abstract read
In one paragraph

Article in Virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chunhua LiThe Viral Oncology Center, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
Eleanor BarnesThe Peter Medawar Building for Pathogen Research, University of Oxford, South Parks Road and Oxford NIHR Biomedical Research Centre, OX1 3SY, UK.
Paul N NewtonLao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao Democratic People's Republic; Centre for Tropical Medicine and Global Health, Churchill Hospital, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
Yongshui FuGuangzhou Blood Center, Guangzhou 510095, China.
Manivanh VongsouvathLao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao Democratic People's Republic.
Paul KlenermanThe Peter Medawar Building for Pathogen Research, University of Oxford, South Parks Road and Oxford NIHR Biomedical Research Centre, OX1 3SY, UK.
Hiroaki OkamotoDivision of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke-shi Tochigi 329-0498, Japan.
Kenji AbeDepartment of Pathology, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo 162-8640, Japan.
Oliver G PybusDepartment of Zoology, University of Oxford, South Parks Road, OX1 3PS, UK.
Ling LuThe Viral Oncology Center, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA. Electronic address: llu@kumc.edu.

Funding

HCV Genotype 6: A Model for HCV Genetics and Molecular Epidemiology StudiesR01AI080734 · NIAID · UNIVERSITY OF UTAH · PI LU, LING · 2009 to 2011
$1.1M
Medical Research Council MR/K010239/1NIAID NIH HHS 5R01AI080734-03ANIAID NIH HHS R01 AI080734Wellcome Trust 091663
6 · The paper itself

Abstract

We characterized the full-length genomes of 22 hepatitis C virus genotype 6 (HCV-6) isolates: 10 from Vietnam (classified into subtypes 6e, 6h, 6p, 6r, 6s, and 6u), one from China (confirmed as a new subtype 6xd), and 11 from the Lao PDR (representing a new subtype 6xe plus eight novel variants). With these 22 new genomes, HCV-6 now has a diverse and extended taxonomic structure, comprised of 28 assigned subtypes (denoted 6a-6xe) and 27 unassigned lineages, all of which have been represented by full-length genomes. Our phylogenetic analyses also included many partially-sequenced novel variants of HCV-6 from Lao PDR. This revealed that Lao HCV isolates are genetically very diverse and are phylogenetically distributed in multiple lineages within genotype 6. Our results suggest that HCV-6 has been maintained in Laos, a landlocked country, since the common ancestor of genotype 6 and indicates historical dispersal of HCV-6 across Southeast Asia.

Indexed as

Genome, ViralAnimalsChinaGenetic VariationGenotypeHepacivirusHepatitis CHumansLaosMolecular Sequence DataPhylogenyVietnamViral ProteinsViral ProteinsFull-length genomeGenotype 6HCVLaosSequence

Identifiers

PMID25589238
PMCPMC4376965

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.