ArticleScientific reports2015
Functional characterization of aquaporins and aquaglyceroporins of the yellow fever mosquito, Aedes aegypti.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 70 citations in OpenAlex.
- Surviving Alpine Winters Without Dehydration: Physiological and Transcriptomic Insights into the Freeze Avoidance ofInsects · 2026Article
- Discovery of an aquaporin (CrAQP2) in the freshwater larval midge,Current research in insect science · 2026Article
- Characterization and deorphanization of RYamide signaling in Aedes aegypti: A potential regulator of hindgut-associated physiology.PloS one · 2026Article
- Physiological and Putative Organic Cation Transporter Expression Response to Alizarin Dye Exposure inInsects · 2025Article
- Morphological and Chemical Changes in the Hemolymph of the Wax MothPathogens (Basel, Switzerland) · 2025Article
- Diuresis and α-glucosidase inhibition by erythritol in Aedes aegypti (Diptera: Culicidae) and viability for efficacy against mosquitoes.Parasites & vectors · 2024Article
- Protein localization of aquaporins in the adult female disease vector mosquito,Frontiers in insect science · 2024Article
- Dehydration Alters Transcript Levels in the Mosquito Midgut, Likely Facilitating Rapid Rehydration following a Bloodmeal.Insects · 2023Article
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- Control of Aedes mosquito populations using recombinant microalgae expressing short hairpin RNAs and their effect on plankton.PLoS neglected tropical diseases · 2023Article
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- Plasmodium metabolite HMBPP stimulates feeding of main mosquito vectors on blood and artificial toxic sources.Communications biology · 2021Article
- Development of an RNAi-based microalgal larvicide for the control of Aedes aegypti.Parasites & vectors · 2021Article
- Delivery Methods for RNAi in Mosquito Larvae.Journal of insect science (Online) · 2020Review
- Specialized stellate cells offer a privileged route for rapid water flux inProceedings of the National Academy of Sciences of the United States of America · 2020Article
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- Enhancing RNAi Efficiency to Decipher the Functional Response of Potential Genes inFrontiers in physiology · 2020Article
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- Using de novo transcriptome assembly and analysis to study RNAi in Phenacoccus solenopsis Tinsley (Hemiptera: Pseudococcidae).Scientific reports · 2019Article
- Using genetic variation in Aedes aegypti to identify candidate anti-dengue virus genes.BMC infectious diseases · 2019Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After taking vertebrate blood, female mosquitoes quickly shed excess water and ions while retaining and concentrating the mostly proteinaceous nutrients. Aquaporins (AQPs) are an evolutionary conserved family of membrane transporter proteins that regulate the flow of water and in some cases glycerol and other small molecules across cellular membranes. In a previous study, we found six putative AQP genes in the genome of the yellow fever mosquito, Ae. aegypti, and demonstrated the involvement of three of them in the blood meal-induced diuresis. Here we characterized AQP expression in different tissues before and after a blood meal, explored the substrate specificity of AQPs expressed in the Malpighian tubules and performed RNAi-mediated knockdown and tested for changes in mosquito desiccation resistance. We found that AQPs are generally down-regulated 24 hrs after a blood meal. Ae. aegypti AQP 1 strictly transports water, AQP 2 and 5 demonstrate limited solute transport, but primarily function as water transporters. AQP 4 is an aquaglyceroporin with multiple substrates. Knockdown of AQPs expressed in the MTs increased survival of Ae. aegypti under dry conditions. We conclude that Malpighian tubules of adult female yellow fever mosquitoes utilize three distinct AQPs and one aquaglyceroporin in their osmoregulatory functions.
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