Observational studyInfection2015
Antibiotic consumption after implementation of a procalcitonin-guided antimicrobial stewardship programme in surgical patients admitted to an intensive care unit: a retrospective before-and-after analysis.
Observational study in Infection, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Value of hospital antimicrobial stewardship programs [ASPs]: a systematic review.Antimicrobial resistance and infection control · 2019Pooled it
- Effectiveness and safety of procalcitonin evaluation for reducing mortality in adults with sepsis, severe sepsis or septic shock.The Cochrane database of systematic reviews · 2017Pooled it
- The Role and Importance of Procalcitonin (PCT) Testing in Rational Antibiotic Prescribing and Antibiotic Stewardship Programs.Immunity, inflammation and disease · 2026Review
- Role of biomarkers in antimicrobial stewardship: physicians' perspectives.The Korean journal of internal medicine · 2024Article
- The cost associated with the development of the antimicrobial stewardship program in the adult general medicine setting in Qatar.Journal of pharmaceutical policy and practice · 2024Article
- Antimicrobial stewardship in the intensive care unit.Journal of intensive medicine · 2023Review
- Antimicrobial Stewardship Using Biomarkers: Accumulating Evidence for the Critically Ill.Antibiotics (Basel, Switzerland) · 2022Review
- Impact of Procalcitonin Levels Combined with Active Intervention on Antimicrobial Stewardship in a Community Hospital.Open forum infectious diseases · 2019Article
- Is antibacterial treatment intensity lower in elderly patients? A retrospective cohort study in a German surgical intensive care unit.BMC health services research · 2019Article
- Interprofessional Antimicrobial Stewardship InfluencingInfection and drug resistance · 2019Article
- [Procalcitonin as a tool for the assessment of successful therapy of severe sepsis : An analysis using clinical routine data].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2018Review
- Adherence to a procalcitonin-guided antibiotic treatment protocol in patients with severe sepsis and septic shock.Annals of intensive care · 2018Article
- Impact of Procalcitonin Monitoring on Duration of Antibiotics in Patients With Sepsis and/or Pneumonia in a Community Hospital Setting.The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2018Article
- [Antibiotic stewardship : Measures for optimizing prescription of anti-infective agents].Der Anaesthesist · 2018Review
- Procalcitonin-guided antibiotic treatment in critically ill patients.Langenbeck's archives of surgery · 2017Review
- Article
- An urgent call for infectious diseases specialists.Infection · 2016Article
- Determinants of Deescalation Failure in Critically Ill Patients with Sepsis: A Prospective Cohort Study.Critical care research and practice · 2016Article
- The impact of tracheotomy on levels of procalcitonin in patients without sepsis: a prospective study.Clinics (Sao Paulo, Brazil) · 2015Observational
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo analyse antibiotic use density (AD)--World Health Organization defined daily doses/1,000 patient-days--before and after implementation of a local antimicrobial stewardship programme (ASP) in conjunction with a procalcitonin (PCT)-guided protocol in a surgical intensive care unit (ICU).
methodsIn this retrospective observational study, data on 2,422 ICU patients between 2010 and 2012 were analysed. In 2011, an ASP in conjunction with a PCT protocol had been introduced into clinical practice. In a multivariate analysis, hospital mortality, length of stay (LOS) in hospital and ICU LOS were adjusted for effects from effective cost weight, gender, and age. AD and changes in the use of antibiotic classes were analysed.
resultsAD decreased from 1,005.0 in 2010 to 791.9 in 2012 which is a total reduction of 21.2%. Consumption of aminoglycosides, cephalosporins and quinolones showed a marked reduction, whereas the use of penicillins did not change significantly. The multivariate models revealed no relevant changes in mortality rate, ICU LOS and hospital LOS.
conclusionsImplementation of an ASP in conjunction with a PCT protocol in 2011 was associated with a marked decrease in total AD and led to a significant change in the spectrum of antibiotics. Clinical outcomes appeared to remain unchanged over the study period.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.