Evidence map›Paper›PMID 25588912›Full record

ReviewCurrent opinion in neurobiology2015

Skilled forelimb movements and internal copy motor circuits.

Eiman Azim, Bror Alstermark

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Trial
  2. Article
  3. A paradigm for skilled forelimb reaching by head-restrained mice.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. iScience · 2022
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. EphA4 Is Required for Neural Circuits Controlling Skilled Reaching.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  15. Article
  16. Article
  17. Article
  18. Gain control in the sensorimotor system.Current opinion in physiology · 2019
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Eiman AzimDepartments of Neuroscience and Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Kavli Institute for Brain Science, Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, United States. Electronic address: ea2471@columbia.edu.
Bror AlstermarkDepartment of Integrative Medical Biology, Section of Physiology, Umeå University, Umeå, Sweden. Electronic address: bror.alstermark@physiol.umu.se.

Funding

Control of Skilled Forelimb Movements by Cerebellar Feedback CircuitsR00NS088193 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI AZIM, EIMAN · 2016 to 2018
$747k
Control of Skilled Forelimb Movements by Cerebellar Feedback CircuitsK99NS088193 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI AZIM, EIMAN · 2014 to 2015
$180k
NINDS NIH HHS K99 NS088193NINDS NIH HHS NS088193NINDS NIH HHS R00 NS088193
6 · The paper itself

Abstract

Mammalian skilled forelimb movements are remarkable in their precision, a feature that emerges from the continuous adjustment of motor output. Here we discuss recent progress in bridging the gap between theory and neural implementation in understanding the basis of forelimb motor refinement. One influential theory is that feedback from internal copy motor pathways enables fast prediction, through a forward model of the limb, an idea supported by behavioral studies that have explored how forelimb movements are corrected online and can adapt to changing conditions. In parallel, neural substrates of forelimb internal copy pathways are coming into clearer focus, in part through the use of genetically tractable animal models to isolate spinal and cerebellar circuits and explore their contributions to movement.

Indexed as

Models, BiologicalAnimalsForelimbHumansMiceMice, TransgenicMotor SkillsMovementNeural Pathways

Identifiers

PMID25588912
PMCPMC4497943

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.