ArticleBioelectrochemistry (Amsterdam, Netherlands)2015
Thromboresistant/anti-biofilm catheters via electrochemically modulated nitric oxide release.
Article in Bioelectrochemistry (Amsterdam, Netherlands), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 54 citations in OpenAlex.
- Nitric oxide-releasing balloon inflation fluid for Foley catheters to prevent catheter-associated urinary tract infections.Microbiology spectrum · 2026Article
- Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Recent developments in preventing catheter-related infections based on biofilms: A comprehensive review.Biomicrofluidics · 2024Review
- Hydrogels for Gasotransmitter Delivery: Nitric Oxide, Carbon Monoxide, and Hydrogen Sulfide.Macromolecular bioscience · 2024Review
- Electrochemical Generation of Nitric Oxide for Medical Applications.Electrochemical science advances · 2022Article
- Smartphone compatible nitric oxide releasing insert to prevent catheter-associated infections.Journal of controlled release : official journal of the Controlled Release Society · 2022Article
- Article
- Development of an artificial placenta for support of premature infants: narrative review of the history, recent milestones, and future innovation.Translational pediatrics · 2021Review
- Assessing and improving the biocompatibility of microfluidic artificial lungs.Acta biomaterialia · 2020Article
- S-Nitroso-N-acetylpenicillamine impregnated endotracheal tubes for prevention of ventilator-associated pneumonia.Biotechnology and bioengineering · 2020Article
- Central line-related bloodstream infections and microbiological study in an Egyptian Ministry of Health Hospital.African health sciences · 2020Article
- Liquid-Infused Nitric-Oxide-Releasing Silicone Foley Urinary Catheters for Prevention of Catheter-Associated Urinary Tract Infections.ACS biomaterials science & engineering · 2019Article
- Extended Nitric Oxide-Releasing Polyurethanes via S-Nitrosothiol-Modified Mesoporous Silica Nanoparticles.ACS applied materials & interfaces · 2019Article
- Inhaled nitric oxide.British journal of pharmacology · 2019Review
- Nitric Oxide Release from Antimicrobial Peptide Hydrogels for Wound Healing.Biomolecules · 2018Article
- Risk factors and microbial profile of central venous catheter related blood stream infection in medical cardiac care units, National Heart Institute, Egypt.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2018Article
- Nitric Oxide Release for Improving Performance of Implantable Chemical Sensors - A Review.Applied materials today · 2017Article
- Portable Nitric Oxide (NO) Generator Based on Electrochemical Reduction of Nitrite for Potential Applications in Inhaled NO Therapy and Cardiopulmonary Bypass Surgery.Molecular pharmaceutics · 2017Article
- Antimicrobial nitric oxide releasing surfaces based on S-nitroso-N-acetylpenicillamine impregnated polymers combined with submicron-textured surface topography.Biomaterials science · 2017Article
- In Vivo Chemical Sensors: Role of Biocompatibility on Performance and Utility.Analytical chemistry · 2017Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Inexpensive nitric oxide (NO) release strategies to prevent thrombosis and bacterial infections are desirable for implantable medical devices. Herein, we demonstrate the utility of electrochemically modulated NO release from a catheter model using an inner copper wire working electrode and an inorganic nitrite salt solution reservoir. These catheters generate NO surface fluxes of >1.0 × 10(-10)mol min(-1) cm(-2) for more than 60 h. Catheters with an NO flux of 1.1 × 10(-10)mol min(-1) cm(-2) are shown to significantly reduce surface thrombus formation when implanted in rabbit veins for 7h. Further, the ability of these catheters to exhibit anti-biofilm properties against bacterial species commonly causing bloodstream and urinary catheter infections is examined. Catheters releasing NO continuously during the 2d growth of Staphylococcus aureus exhibit a 6 log-unit reduction in viable surface bacteria. We also demonstrate that catheters generating NO for only 3h at a flux of 1.0 × 10(-10)mol min(-1) cm(-2) lower the live bacterial counts of both 2d and 4d pre-formed Escherichia coli biofilms by >99.9%. Overall, the new electrochemical NO-release devices could provide a cost-effective strategy to greatly enhance the biocompatibility and antimicrobial properties of intravascular and urinary catheters, as well as other implantable medical devices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.