ArticleScientific reports2015
Biological interaction of living cells with COSAN-based synthetic vesicles.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- [60]Fullerene-Cluster Hybrids as Boron-Dense Delivery Nanoplatforms.Small science · 2026Article
- Antifungal metallacarboranes modulate Hsp90 activity.Future medicinal chemistry · 2026Article
- Functionalizing Injectable Hydrogels with Cobalt-Based Metallacarboranes for Targeted Delivery in Triple-Negative Breast Cancer.Chembiochem : a European journal of chemical biology · 2025Article
- Assessment of Carrier-Free Metallacarboranes for Targeted Radiation Therapies PBFT and BNCT: Comparative Cellular Effects and Dosimetry Studies with [Pharmaceuticals (Basel, Switzerland) · 2025Article
- Anionic Boron-Cluster BODIPY Conjugates As Promising Photosensitizers for Targeted Antimicrobial Photodynamic Therapy.ACS omega · 2025Article
- Metallacarboranes: abiotic scaffolds for advanced drug discovery.Future medicinal chemistry · 2025Article
- Enhancing Boron Neutron Capture Therapy (BNCT) with Materials Based on COSAN-Functionalized Nanoparticles.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Boron Cluster Anions Dissolve En Masse in Lipids Causing Membrane Expansion and Thinning.Angewandte Chemie (International ed. in English) · 2024Article
- Carbon-Substituted Amines of the Cobalt Bis(dicarbollide) Ion: Stereochemistry and Acid-Base Properties.Inorganic chemistry · 2024Article
- Cobaltabis(Dicarbollide) [Pharmaceuticals (Basel, Switzerland) · 2024Article
- Expanding the Range of Bioorthogonal Tags for Multiplex Stimulated Raman Scattering Microscopy.Angewandte Chemie (International ed. in English) · 2023Article
- New Boron Containing Acridines: Synthesis and Preliminary Biological Study.Molecules (Basel, Switzerland) · 2023Article
- Metallacarborane Cluster Anions of the Cobalt Bisdicarbollide-Type as Chaotropic Carriers for Transmembrane and Intracellular Delivery of Cationic Peptides.Journal of the American Chemical Society · 2023Article
- Towards the Application of Purely Inorganic Icosahedral Boron Clusters in Emerging Nanomedicine.Molecules (Basel, Switzerland) · 2023Review
- Metallacarborane Synthons for Molecular Construction-Oligofunctionalization of Cobalt Bis(1,2-dicarbollide) on Boron and Carbon Atoms with Extendable Ligands.Molecules (Basel, Switzerland) · 2023Article
- New Boron Delivery Agents.Cancer biotherapy & radiopharmaceuticals · 2023Review
- History of Cobaltabis(dicarbollide) in Potentiometry, No Need for Ionophores to Get an Excellent Selectivity.Molecules (Basel, Switzerland) · 2022Review
- Synthesis of Cobalt Bis(Dicarbollide)-Curcumin Conjugates for Potential Use in Boron Neutron Capture Therapy.Molecules (Basel, Switzerland) · 2022Article
- Carboranes in drug discovery, chemical biology and molecular imaging.Nature reviews. Chemistry · 2022Review
- Synthesis and Antibacterial Activity Studies of the Conjugates of Curcumin withMolecules (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cobaltabisdicarbollide (COSAN) [3,3'-Co(1,2-C2B9H11)2](-), is a complex boron-based anion that has the unusual property of self-assembly into membranes and vesicles. These membranes have similar dimensions to biological membranes found in cells, and previously COSAN has been shown to pass through synthetic lipid membranes and those of living cells without causing breakdown of membrane barrier properties. Here, we investigate the interaction of this inorganic membrane system with living cells. We show that COSAN has no immediate effect on cell viability, and cells fully recover when COSAN is removed following exposure for hours to days. COSAN elicits a range of cell biological effects, including altered cell morphology, inhibition of cell growth and, in some cases, apoptosis. These observations reveal a new biology at the interface between inorganic, synthetic COSAN membranes and naturally occurring biological membranes.
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