Evidence map›Paper›PMID 25588658›Full record

ArticleJournal of clinical microbiology2015

Detection of a transient R292K mutation in influenza A/H3N2 viruses shed for several weeks by an immunocompromised patient.

N Esther Babady, Jennifer M Laplante, Yi-Wei Tang, Kirsten St George

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Journal of clinical microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Guideline
  2. Journal of virology · 2020
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

N Esther BabadyClinical Microbiology Service, Department of Laboratory Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA babadyn@mskcc.org.ORCID http://orcid.org/0000-0003-4399-1249
Jennifer M LaplanteLaboratory of Viral Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
Yi-Wei TangClinical Microbiology Service, Department of Laboratory Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.ORCID http://orcid.org/0000-0003-4888-6771
Kirsten St GeorgeLaboratory of Viral Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
Memorial Sloan Kettering Cancer Center · USNew York State Department of Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe the case of an immunocompromised patient, positive for influenza A virus (H3N2), in whom the neuraminidase R292K mutation was transiently detected during oseltamivir treatment. The R292K mutation was identified by direct testing in 3 of 11 respiratory specimens collected throughout the patient's illness but in none of the cultures from those specimens.

Indexed as

Immunocompromised HostAntiviral AgentsGene Expression Regulation, ViralHumansInfluenza A Virus, H3N2 SubtypeInfluenza, HumanMaleMiddle AgedMutationNeuraminidaseOseltamivirReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionVirus SheddingAntiviral AgentsNeuraminidaseOseltamivir

Identifiers

PMID25588658
PMCPMC4365243
OpenAlexW2155705978

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.