ArticleJournal of clinical microbiology2015
Multicenter evaluation of the BioFire FilmArray gastrointestinal panel for etiologic diagnosis of infectious gastroenteritis.
Article in Journal of clinical microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04269174 (The Utility of Biofire Filmarray in Evaluation of Entero Pathogens Triggers in Patients With Chronic Diarrhea), which is not on this map. Cited by 259 papers, 6 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Utility of Biofire Filmarray in Evaluation of Entero Pathogens Triggers in Patients With Chronic Diarrhea
Who cites it
259 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- A comparison of frequentist and Bayesian methods for meta-analysis of diagnostic test accuracy studies.Epidemiology and infection · 2026Pooled it
- Systematic review of point-of-need molecular diagnostics for rotavirus and enteric adenoviruses F40/F41.BMC infectious diseases · 2026Pooled it
- Diagnostic Accuracy of Multiplex NAAT/PCR and Culture AgainstPathogens (Basel, Switzerland) · 2025Pooled it
- A systematic review and meta-analysis of the global prevalence of human enteric adenovirus infections.Journal of infection and public health · 2025Pooled it
- Diagnostic accuracy of multiplex nucleic acid amplification tests forPathogens and global health · 2023Pooled it
- Accuracy and comparison of two rapid multiplex PCR tests for gastroenteritis pathogens: a systematic review and meta-analysis.BMJ open gastroenterology · 2021Pooled it
- Clinical Impact of Multiplex Molecular Diagnostic Testing in Children With Acute Gastroenteritis Presenting to an Emergency Department: A Multicenter Prospective Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Trial
- Gut microbiome alteration in MORDOR I: a community-randomized trial of mass azithromycin distribution.Nature medicine · 2019Trial
- Evaluation of false positive enteric viruses results from the BIOFIRE® FILMARRAY® gastrointestinal PCR panel.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2026Article
- Clinical characteristics and outcomes of bacterial and viral gastrointestinal infection by pathogen: a large-scale observational study in United States.Journal of gastroenterology · 2026Article
- Multicentre Evaluation of Cepheid XpertMicroorganisms · 2026Article
- Severe Undernutrition Predicts Adverse Outcomes in Transplant Norovirus Infection.Kidney international reports · 2026Article
- Article
- Molecular characterization of norovirus false-positive results on the BioFire FilmArray gastrointestinal panel.Journal of clinical microbiology · 2026Article
- Effect of Diagnostic Test Type on Detection of Salmonella Infections - Foodborne Diseases Active Surveillance Network, 2004-2024.MMWR. Morbidity and mortality weekly report · 2026Article
- Twenty-Two Months of Syndromic Multiplex-PCR Testing for Acute Infections in a Southern Italian Hospital: Pathogen Epidemiology, Diagnostic Appropriateness and the Cost of Negative Results.Microorganisms · 2026Article
- Molecular detection of pathogens associated with childhood gastroenteritis in Burkina Faso using the FilmArrayBMC infectious diseases · 2026Article
- Diagnostic performance of the QIAstat-Dx gastrointestinal panel compared with conventional methods in pediatric gastroenteritis.Microbiology spectrum · 2026Article
- Chronic exposure to intestinal parasites and bacterial enteropathogens among children in rural Madagascar: Implications for asymptomatic carriage and co-infections.PLoS neglected tropical diseases · 2026Article
- Contributions of whole-genome sequencing to the epidemiological monitoring ofAntimicrobial agents and chemotherapy · 2026Article
199 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The appropriate treatment and control of infectious gastroenteritis depend on the ability to rapidly detect the wide range of etiologic agents associated with the disease. Clinical laboratories currently utilize an array of different methodologies to test for bacterial, parasitic, and viral causes of gastroenteritis, a strategy that suffers from poor sensitivity, potentially long turnaround times, and complicated ordering practices and workflows. Additionally, there are limited or no testing methods routinely available for most diarrheagenic Escherichia coli strains, astroviruses, and sapoviruses. This study assessed the performance of the FilmArray Gastrointestinal (GI) Panel for the simultaneous detection of 22 different enteric pathogens directly from stool specimens: Campylobacter spp., Clostridium difficile (toxin A/B), Plesiomonas shigelloides, Salmonella spp., Vibrio spp., Vibrio cholerae, Yersinia enterocolitica, enteroaggregative E. coli, enteropathogenic E. coli, enterotoxigenic E. coli, Shiga-like toxin-producing E. coli (stx1 and stx2) (including specific detection of E. coli O157), Shigella spp./enteroinvasive E. coli, Cryptosporidium spp., Cyclospora cayetanensis, Entamoeba histolytica, Giardia lamblia, adenovirus F 40/41, astrovirus, norovirus GI/GII, rotavirus A, and sapovirus. Prospectively collected stool specimens (n = 1,556) were evaluated using the BioFire FilmArray GI Panel and tested with conventional stool culture and molecular methods for comparison. The FilmArray GI Panel sensitivity was 100% for 12/22 targets and ≥94.5% for an additional 7/22 targets. For the remaining three targets, sensitivity could not be calculated due to the low prevalences in this study. The FilmArray GI Panel specificity was ≥97.1% for all panel targets. The FilmArray GI Panel provides a comprehensive, rapid, and streamlined alternative to conventional methods for the etiologic diagnosis of infectious gastroenteritis in the laboratory setting. The potential advantages include improved performance parameters, a more extensive menu of pathogens, and a turnaround time of as short as 1 h.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.