Evidence map›Paper›PMID 25588568›Full record

SynthesisCritical care (London, England)2015

Preoperative intra-aortic balloon pump to reduce mortality in coronary artery bypass graft: a meta-analysis of randomized controlled trials.

Alberto Zangrillo, Federico Pappalardo, Roberto Dossi, Ambra Licia Di Prima, Marta Eugenia Sassone, Teresa Greco, Fabrizio Monaco, Mario Musu, Gabriele Finco, Giovanni Landoni

Abstract readMeta-AnalysisReview
In one paragraph

Synthesis in Critical care (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Observational
  3. Article
  4. Preoperative intra-aortic balloon pump in patients with ST-elevation myocardial infarction undergoing urgent cardiac bypass surgery.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Observational
  10. Article
  11. CABG in patients with left ventricular dysfunction: indications, techniques and outcomes.Indian journal of thoracic and cardiovascular surgery · 2018
    Review
  12. Article
  13. Article
  14. Observational
  15. Article
  16. Review
  17. Article
  18. Article
  19. Traumatic blunt cardiac injuries: An updated narrative review.International journal of critical illness and injury science
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alberto ZangrilloDepartment of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, 20132, Italy. zangrillo.alberto@hsr.it.
Federico PappalardoDepartment of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, 20132, Italy. pappalardo.federico@hsr.it.
Roberto DossiDepartment of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, 20132, Italy. roberto.dossi87@gmail.com.
Ambra Licia Di PrimaDepartment of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, 20132, Italy. ambra.diprima@gmail.com.
Marta Eugenia SassoneDepartment of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, 20132, Italy. antigone47@libero.itl.
Teresa GrecoDepartment of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, 20132, Italy. greco.teresa@hotmail.it.
Fabrizio MonacoDepartment of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, 20132, Italy. monaco.fabrizio@hsr.it.
Mario MusuDepartment of Medical Sciences "M. Aresu", Cagliari University, Bivio di Sestu 554, 09042, Monserrato, Cagliari, Italy. mmusu@medicina.unica.it.
Gabriele FincoDepartment of Medical Sciences "M. Aresu", Cagliari University, Bivio di Sestu 554, 09042, Monserrato, Cagliari, Italy. gabriele.finco@gmail.com.
Giovanni LandoniDepartment of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, 20132, Italy. landoni.giovanni@hsr.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe intra-aortic balloon pump is routinely used in cardiac surgery; however, its impact on outcome is still a matter of debate and several randomized trials have been published recently. We perform an updated meta-analysis of randomized controlled trials that investigated the use of preoperative intra-aortic balloon pump in adult patients undergoing coronary artery bypass grafting.

methodsPotentially eligible trials were identified by searching the Medline, Embase, Scopus, ISI Web of Knowledge and The Cochrane Library. Searches were not restricted by language or publication status and were updated in August 2014. Randomized controlled trials on preoperative intra-aortic balloon pump in patients undergoing coronary artery bypass grafting either with or without cardiopulmonary bypass were identified. The primary end point was mortality at the longest follow-up available and the secondary end point was 30-day mortality.

resultsThe eight included randomized clinical trials enrolled 625 patients (312 to the intra-aortic balloon pump group and 313 to control). The use of intra-aortic balloon pump was associated with a significant reduction in the risk of mortality (11 of 312 (3.5%) versus 33 of 313 (11%), risk ratio = 0.38 (0.20 to 0.73), P for effect = 0.004, P for heterogeneity = 0.7, I-square = 0%, with eight studies included). The benefit on mortality reduction was confirmed restricting the analysis to trials with low risk of bias, to those reporting 30-day follow-up and to patients undergoing coronary artery bypass graft surgery with cardiopulmonary bypass.

conclusionsPreoperative intra-aortic balloon pump reduces perioperative and 30-day mortality in high-risk patients undergoing elective coronary artery bypass grafting.

Indexed as

Cardiopulmonary BypassCoronary Artery BypassHumansIntra-Aortic Balloon PumpingPostoperative ComplicationsPreoperative CareRandomized Controlled Trials as TopicRisk FactorsSurvival Rate

Identifiers

PMID25588568
PMCPMC4316767

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.