Evidence map›Paper›PMID 25588524›Full record

ArticleClinical and translational gastroenterology2015

Effect of exclusive enteral nutrition on the microbiota of children with newly diagnosed Crohn's disease.

Nadeem O Kaakoush, Andrew S Day, Steven T Leach, Daniel A Lemberg, Shaun Nielsen, Hazel M Mitchell

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and translational gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 3 pooled it
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 112 citations in OpenAlex.

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  17. Metabolic changes during exclusive enteral nutrition in pediatric Crohn's disease patients.Metabolomics : Official journal of the Metabolomic Society · 2022
    Article
  18. Review article: the future of microbiome-based therapeutics.Alimentary pharmacology & therapeutics · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Nadeem O KaakoushSchool of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, Australia.
Andrew S Day1] Department of Gastroenterology, Sydney Children's Hospital, Sydney, Australia [2] Department of Paediatrics, University of Otago, Christchurch, New Zealand [3] School of Women's and Children's Health, The University of New South Wales, Sydney, Australia.
Steven T LeachSchool of Women's and Children's Health, The University of New South Wales, Sydney, Australia.
Daniel A LembergDepartment of Gastroenterology, Sydney Children's Hospital, Sydney, Australia.
Shaun NielsenSchool of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, Australia.
Hazel M MitchellSchool of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, Australia.
UNSW Sydney · AUSydney Children's Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesExclusive enteral nutrition (EEN) is commonly used to treat pediatric Crohn's disease (CD). Meta-analysis of pediatric studies that have compared the effect of EEN with other treatments have shown that EEN induces remission in up to 80-85% of patients. We aimed to gain a comprehensive understanding of the effect of EEN on the microbiota of CD patients.

methodsWe used 16S rRNA gene and whole-genome high throughout sequencing to determine changes in the fecal microbiota of five CD children, before, during, and after EEN therapy and compared this with five healthy controls.

resultsThe microbial diversity observed in CD patients tended to be lower than that in controls (CD: 2.25±0.24, controls: 2.75±0.14, P=0.11). In all CD patients, dysbiosis was observed prior to therapy. EEN therapy had a positive effect in all patients, with 80% going into remission. In some patients, the positive effect diminished following the conclusion of EEN therapy. Significantly, the number of operational taxonomic units (OTU) decreased dramatically upon starting EEN and this corresponded with CD remission. Recurrence of CD corresponded with an increase in OTUs. Six families within the Firmicutes were found to correlate with disease activity during and following EEN therapy, a finding that was confirmed by whole-genome high throughput sequencing.

conclusionsOur results demonstrate that EEN leads to common and patient-specific alterations in the microbiota of CD patients, a number of which correlate with disease activity.

Identifiers

PMID25588524
PMCPMC4418409
OpenAlexW1994760300

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.