ArticleTheoretical biology & medical modelling2015
Modeling drug resistance in a conjoint normal-tumor setting.
Article in Theoretical biology & medical modelling, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Dynamics of Breast Cancer under Different Rates of Chemoradiotherapy.Computational and mathematical methods in medicine · 2019Article
- MicroRNA pharmacogenomics based integrated model of miR-17-92 cluster in sorafenib resistant HCC cells reveals a strategy to forestall drug resistance.Scientific reports · 2017Article
- Modeling multi-mutation and drug resistance: analysis of some case studies.Theoretical biology & medical modelling · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn this paper, we modify our previously developed conjoint tumor-normal cell model in order to make a distinction between tumor cells that are responsive to chemotherapy and those that may show resistance.
resultsUsing this newly developed core model, the evolution of three cell types: normal, tumor, and drug-resistant tumor cells, is studied through a series of numerical simulations. In addition, we illustrate critical factors that cause different dynamical patterns for normal and tumor cells. Among these factors are the co-dependency of the normal and tumor cells, the cells' response mechanism to a single or multiple chemotherapeutic treatment, the drug administration sequence, and the treatment starting time.
conclusionThe results provide us with a deeper understanding of the possible evolution of normal, drug-responsive, and drug-resistant tumor cells during the cancer progression, which may contribute to improving the therapeutic strategies.
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