ArticleAmerican journal of Alzheimer's disease and other dementias2015
Serum sEPCR levels are elevated in patients with Alzheimer's disease.
Article in American journal of Alzheimer's disease and other dementias, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 11 citations in OpenAlex.
- Identification of novel diagnostic panel for mild cognitive impairment and Alzheimer's disease: findings based on urine proteomics and machine learning.Alzheimer's research & therapy · 2023Article
- Review
- Hemostasis components in cerebral amyloid angiopathy and Alzheimer's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Review
- The effects of coagulation factors on the risk of Alzheimer's disease: A Mendelian randomization study.Journal of Alzheimer's disease reportsArticle
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Authors and funding
4 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Blood-brain barrier impairment and endothelial cell dysfunction have both been implicated in the pathogenesis of Alzheimer's disease (AD). The presence of vascular risk factors is also known to increase the risk of AD. Soluble endothelial protein C receptor (sEPCR) should thus produce procoagulant and proinflammatory effects. Serum sEPCR levels have been found to be associated with several diseases. To date, no reports have been published regarding serum sEPCR levels in AD. In this study, we found that serum sEPCR levels were significantly increased in patients with AD when compared to control participants (P = .0005). There was no significant difference between patients with mild cognitive impairment (MCI) and healthy controls (P = .055) or between patients with AD and MCI (P = .054). Importantly, our results also indicate that the degree of cognitive impairment is significantly correlated with serum sEPCR levels in all patients and healthy controls. These findings suggest that serum sEPCR levels could be a potential candidate for a biomarker panel for AD diagnosis.
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