ReviewObesity reviews : an official journal of the International Association for the Study of Obesity2015
Metabolic vs. hedonic obesity: a conceptual distinction and its clinical implications.
Review in Obesity reviews : an official journal of the International Association for the Study of Obesity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa.The American journal of psychiatry · 2017Pooled it
- Pharmaceutical interventions for weight-loss maintenance: no effect from cabergoline.International journal of obesity (2005) · 2018Trial
- Nighttime sleep duration and hedonic eating in childhood.International journal of obesity (2005) · 2015Trial
- LEAP2 as a therapeutic target in obesity and cardiometabolic disorders.Reviews in endocrine & metabolic disorders · 2026Review
- Association of Students' Nutritional Behaviors with Insulin Resistance and Body Measurements.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Improving the diagnosis of hyperphagia in melanocortin-4 receptor pathway diseases.Obesity (Silver Spring, Md.) · 2025Review
- Association of obesogenic environment and hedonic appetite with chronic fatigue in Turkish adults.Frontiers in nutrition · 2025Article
- Molecular Mechanisms behind Obesity and Their Potential Exploitation in Current and Future Therapy.International journal of molecular sciences · 2024Review
- Role of Endogenous Opioids in the Pathophysiology of Obesity and Eating Disorders.Advances in neurobiology · 2024Review
- Bean Leaves Ameliorate Lipotoxicity in Fatty Liver Disease.Nutrients · 2023Article
- Position statement on nutrition therapy for overweight and obesity: nutrition department of the Brazilian association for the study of obesity and metabolic syndrome (ABESO-2022).Diabetology & metabolic syndrome · 2023Review
- Reward Processing During Monetary Incentive Delay Task After Leptin Substitution in Lipodystrophy-an fMRI Case Series.Journal of the Endocrine Society · 2023Article
- Attentional bias for high-calorie food cues by the level of hunger and satiety in individuals with binge eating behaviors.Frontiers in neuroscience · 2023Article
- Severe Obesity in Women Can Lead to Worse Memory Function and Iron Dyshomeostasis Compared to Lower Grade Obesity.International journal of endocrinology · 2023Article
- Added flavors: potential contributors to body weight gain and obesity?BMC medicine · 2022Article
- miRNA signatures associated with vulnerability to food addiction in mice and humans.The Journal of clinical investigation · 2022Article
- Obesity I: Overview and molecular and biochemical mechanisms.Biochemical pharmacology · 2022Review
- Obesity as a Condition Determined by Food Addiction: Should Brain Endocannabinoid System Alterations Be the Cause and Its Modulation the Solution?Pharmaceuticals (Basel, Switzerland) · 2021Review
- Evaluation and Management of Early Onset Genetic Obesity in Childhood.Journal of pediatric genetics · 2021Review
- Dietary Management of Obesity: A Review of the Evidence.Diagnostics (Basel, Switzerland) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Body weight is determined via both metabolic and hedonic mechanisms. Metabolic regulation of body weight centres around the 'body weight set point', which is programmed by energy balance circuitry in the hypothalamus and other specific brain regions. The metabolic body weight set point has a genetic basis, but exposure to an obesogenic environment may elicit allostatic responses and upward drift of the set point, leading to a higher maintained body weight. However, an elevated steady-state body weight may also be achieved without an alteration of the metabolic set point, via sustained hedonic over-eating, which is governed by the reward system of the brain and can override homeostatic metabolic signals. While hedonic signals are potent influences in determining food intake, metabolic regulation involves the active control of both food intake and energy expenditure. When overweight is due to elevation of the metabolic set point ('metabolic obesity'), energy expenditure theoretically falls onto the standard energy-mass regression line. In contrast, when a steady-state weight is above the metabolic set point due to hedonic over-eating ('hedonic obesity'), a persistent compensatory increase in energy expenditure per unit metabolic mass may be demonstrable. Recognition of the two types of obesity may lead to more effective treatment and prevention of obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.