Evidence map›Paper›PMID 25588099›Full record

ArticleOrganic & biomolecular chemistry2015

Functional chromatographic technique for natural product isolation.

Eric C Lau, Damian J Mason, Nicole Eichhorst, Pearce Engelder, Celestina Mesa, E M Kithsiri Wijeratne, G M Kamal B Gunaherath, A A Leslie Gunatilaka, James J La Clair, Eli Chapman

Abstract read
In one paragraph

Article in Organic & biomolecular chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Lessons in Organic Fluorescent Probe Discovery.Chembiochem : a European journal of chemical biology · 2021
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Inhibitors of the AAA+ chaperone p97.Molecules (Basel, Switzerland) · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eric C LauCollege of Pharmacy, Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ 85721-0207, USA. chapman@pharmacy.arizona.edu.
Damian J Mason
Nicole Eichhorst
Pearce Engelder
Celestina Mesa
E M Kithsiri Wijeratne
G M Kamal B Gunaherath
A A Leslie Gunatilaka
James J La Clair
Eli Chapman

Funding

SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI DEAN BILLHEIMER · 1994 to 2026
$36.7M
Anticancer Agents from Plant- and Lichen-Associated Fungi of the Sonoran DesertR01CA090265 · NCI · UNIVERSITY OF ARIZONA · PI GUNATILAKA, LESLIE · 2002 to 2013
$2.2M
Stress response, p97, and Nrf2 in arsenic-mediated toxicityR01ES023758 · NIEHS · UNIVERSITY OF ARIZONA · PI CHAPMAN, ELI, ZHANG, DONNA D · 2014 to 2018
$1.6M
NCI NIH HHS R01 CA090265NCI NIH HHS R01 CA90265NIEHS NIH HHS ES006694NIEHS NIH HHS R01 ES023758NIEHS NIH HHS R01 ES023875
6 · The paper itself

Abstract

Natural product discovery arises through a unique interplay between chromatographic purification and biological assays. Currently, most techniques used for natural product purification deliver leads without a defined biological action. We now describe a technique, referred to herein as functional chromatography, that deploys biological affinity as the matrix for compound isolation.

Indexed as

Biological ProductsChromatographyBiological Products

Identifiers

PMID25588099
PMCPMC4576851

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.