ArticleJournal of biomechanical engineering2015
Mechanical platelet activation potential in abdominal aortic aneurysms.
Article in Journal of biomechanical engineering, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 54 citations in OpenAlex.
- Association of Intraluminal Thrombus, Hemodynamic Forces, and Abdominal Aortic Aneurysm Expansion Using Longitudinal CT Images.Annals of biomedical engineering · 2016Trial
- Platelet-hitchhike nanomedicine for theranostics of coronary artery dissection via X-CT imaging and inhibiting NLRP3 signaling pathway.Journal of nanobiotechnology · 2026Article
- Efficacy and Safety of Antiplatelet Therapy After Endovascular Aortic Repair: A Target Trial Emulation.Journal of the American Heart Association · 2025Observational
- A numerical study of the effect of thrombus breakdown on predicted thrombus formation and growth.Biomechanics and modeling in mechanobiology · 2024Article
- Antiplatelet Therapy, Abdominal Aortic Aneurysm Progression, and Clinical Outcomes.JAMA network open · 2023Article
- A fibrin enhanced thrombosis model for medical devices operating at low shear regimes or large surface areas.PLoS computational biology · 2022Article
- The Detrimental Role of Intraluminal Thrombus Outweighs Protective Advantage in Abdominal Aortic Aneurysm Pathogenesis: The Implications for the Anti-Platelet Therapy.Biomolecules · 2022Review
- Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms.The Journal of clinical investigation · 2022Article
- Models of Shear-Induced Platelet Activation and Numerical Implementation With Computational Fluid Dynamics Approaches.Journal of biomechanical engineering · 2022Article
- P-Selectin Glycoprotein Ligand-1 Deficiency Protects Against Aortic Aneurysm Formation Induced by DOCA Plus Salt.Cardiovascular drugs and therapy · 2022Article
- Targeting Platelet Activation in Abdominal Aortic Aneurysm: Current Knowledge and Perspectives.Biomolecules · 2022Review
- Platelet function changes in patients undergoing endovascular aortic aneurysm repair: Review of the literature.Frontiers in cardiovascular medicine · 2022Review
- Patient specific approach to analysis of shear-induced platelet activation in haemodialysis arteriovenous fistula.PloS one · 2022Article
- Effects of cardiac function alterations on the risk of postoperative thrombotic complications in patients receiving endovascular aortic repair.Frontiers in physiology · 2022Article
- Computational modeling of blood component transport related to coronary artery thrombosis in Kawasaki disease.PLoS computational biology · 2021Article
- Assessing the methodology used to study the ascending aorta haemodynamics in bicuspid aortic valve.European heart journal. Digital health · 2021Article
- Platelet activation via dynamic conformational changes of von Willebrand factor under shear.PloS one · 2020Article
- Genomic Variations in Susceptibility to Intracranial Aneurysm in the Korean Population.Journal of clinical medicine · 2019Article
- Si-Miao-Yong-An Decoction Protects Against Cardiac Hypertrophy and Dysfunction by Inhibiting Platelet Aggregation and Activation.Frontiers in pharmacology · 2019Article
- Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Intraluminal thrombus (ILT) in abdominal aortic aneurysms (AAA) has potential implications to aneurysm growth and rupture risk; yet, the mechanisms underlying its development remain poorly understood. Some researchers have proposed that ILT development may be driven by biomechanical platelet activation within the AAA, followed by adhesion in regions of low wall shear stress. Studies have investigated wall shear stress levels within AAA, but platelet activation potential (AP) has not been quantified. In this study, patient-specific computational fluid dynamic (CFD) models were used to analyze stress-induced AP within AAA under rest and exercise flow conditions. The analysis was conducted using Lagrangian particle-based and Eulerian continuum-based approaches, and the results were compared. Results indicated that biomechanical platelet activation is unlikely to play a significant role for the conditions considered. No consistent trend was observed in comparing rest and exercise conditions, but the functional dependence of AP on stress magnitude and exposure time can have a large impact on absolute levels of anticipated platelet AP. The Lagrangian method obtained higher peak AP values, although this difference was limited to a small percentage of particles that falls below reported levels of physiologic background platelet activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.