Evidence map›Paper›PMID 25587943›Full record

ReviewEpigenetics2015

Epigenetic regulation in human melanoma: past and future.

Debina Sarkar, Euphemia Y Leung, Bruce C Baguley, Graeme J Finlay, Marjan E Askarian-Amiri

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Epigenetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 171 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
171citing papers in PubMed, 1 pooled it
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

171 citing papers in PubMed, 1 synthesis or guideline pooled it, 302 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  12. Ubiquitination in hepatocellular carcinoma immunity.Journal of translational medicine · 2025
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  20. Recent advances in the genetic engineering of theIranian journal of basic medical sciences · 2025
    Review

111 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Debina Sarkara Auckland Cancer Society Research Center ; University of Auckland ; Auckland , New Zealand.
Euphemia Y Leung
Bruce C Baguley
Graeme J Finlay
Marjan E Askarian-Amiri
Cancer Society of New Zealand · NZUniversity of Auckland · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development and progression of melanoma have been attributed to independent or combined genetic and epigenetic events. There has been remarkable progress in understanding melanoma pathogenesis in terms of genetic alterations. However, recent studies have revealed a complex involvement of epigenetic mechanisms in the regulation of gene expression, including methylation, chromatin modification and remodeling, and the diverse activities of non-coding RNAs. The roles of gene methylation and miRNAs have been relatively well studied in melanoma, but other studies have shown that changes in chromatin status and in the differential expression of long non-coding RNAs can lead to altered regulation of key genes. Taken together, they affect the functioning of signaling pathways that influence each other, intersect, and form networks in which local perturbations disturb the activity of the whole system. Here, we focus on how epigenetic events intertwine with these pathways and contribute to the molecular pathogenesis of melanoma.

Indexed as

Epigenesis, GeneticGene Expression Regulation, NeoplasticCarcinogenesisChromatin Assembly and DisassemblyDNA MethylationHistonesHumansMelanomaProtein Processing, Post-TranslationalProto-Oncogene MasRNA, Long NoncodingSignal TransductionHistonesMAS1 protein, humanProto-Oncogene MasRNA, Long Noncoding5hmC, 5-hydroxymethylcytosine5mC, 5-methylcytosineACE, angiotensin converting enzymeANCR, anti-differentiation non-coding RNAANRIL, antisense noncoding RNA in INK4 locusASK1, apoptosis signal-regulating kinase 1ATRA, all-trans retinoic acidBANCR, BRAF-activated non-coding RNABCL-2, B-cell lymphoma 2BRAF, B-Raf proto-oncogene, serine/threonine kinaseBRG1, ATP-dependent helicase SMARCA4CAF-1, chromatin assembly factor-1CBX7, chromobox homolog 7CCND1, cyclin D1CD28, cluster of differentiation 28Cdc6, cell division cycle 6CDK, cyclin-dependent kinaseCDKN2A/B, cyclin-dependent kinase inhibitor 2A/BceRNA, competitive endogenous RNAsCHD8, chromodomain-helicase DNA-binding protein 8chromatin modificationchromatin remodelingCREB, cAMP response element-binding proteinCUDR, cancer upregulated drug resistantDNA methylation/demethylationDNMT, DNA methyltransferaseEMT, epithelial-mesenchymal transitionepigeneticsERK, extracellular signal-regulated kinaseEZH2, enhancer of zeste homolog 2gene regulationGPCRs, G-protein coupled receptorsGSK3a, glycogen synthase kinase 3 αGWAS, genome-wide association studyHDAC, histone deacetylaseHOTAIR, HOX antisense intergenic RNAIAP, inhibitor of apoptosisIDH2, isocitrate dehydrogenaseIFN, interferon, interleukin 23Jak/STAT, Janus kinase/signal transducer and activator of transcriptionJNK, Jun N-terminal kinaselncRNA, long ncRNAMAFG, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog GMALAT1, metastasis-associated lung adenocarcinoma transcript 1MAPK, mitogen-activated protein kinaseMC1R, melanocortin-1 receptorMeCP2, methyl CpG binding protein 2melanomaMGMT, O6-methylguanine-DNA methyltransferaseMIF, macrophage migration inhibitory factormiRNA, micro RNAMITF, microphthalmia-associated transcription factorMRE, miRNA recognition elementncRNA, non-coding RNAncRNAsNF-κB, nuclear factor kappa-light-chain-enhancer of activated B cellsNOD, nucleotide-binding and oligomerization domainp14ARF, p14 alternative reading framep16INK4a, p16 inhibitor of CDK4PBX, pre-B-cell leukemia homeoboxPEDF, pigment epithelium derived factorPI3K, phosphatidylinositol-4, 5-bisphosphate 3-kinasePIB5PA, phosphatidylinositol-4, 5-biphosphate 5-phosphatase APKA, protein kinase ApRB, retinoblastoma proteinPRC, polycomb repressor complexPSF, PTB associated splicing factorPTB, polypyrimidine tract-bindingPTEN, phosphatase and tensin homologRARB, retinoic acid receptor-β2RASSF1A, Ras association domain family 1ASETDB1, SET Domain, bifurcated 1snoRNA, small nucleolar RNASPRY4, Sprouty 4STAU1, Staufen1SWI/SNF, SWItch/Sucrose Non-FermentableTCR, T-cell receptorTET, ten eleven translocaseTGF β, transforming growth factor βTINCR, tissue differentiation-inducing non-protein coding RNATOR, target of rapamycinTP53, tumor protein 53TRAF6, TNF receptor-associated factor 6UCA1, urothelial carcinoma-associated 1α-MSHm, α-melanocyte stimulating hormone

Identifiers

PMID25587943
PMCPMC4622872
OpenAlexW1490559159

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.