ArticleCase reports in gastrointestinal medicine2014
Metastatic hepatocellular carcinoma in a patient with Crohn's disease treated with azathioprine and infliximab: a case report and literature review.
Article in Case reports in gastrointestinal medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Non-cirrhotic hepatocellular carcinoma during Crohn's disease therapy with azathioprine : possible involvement of focal hepatocyte glycogenosis in hepatocarcinogenesis.Clinical journal of gastroenterology · 2026Article
- Article
- Metastatic Hepatocellular Carcinoma into the Transverse Colon.Journal of gastrointestinal cancer · 2019Article
- Hepatic complications induced by immunosuppressants and biologics in inflammatory bowel disease.World journal of hepatology · 2017Review
- Recurrent Hepatocellular Carcinoma in Patient with Crohn's Disease: Incidental or Expected Outcome of Azathioprine?Case reports in gastrointestinal medicine · 2015Article
- Resected Hepatocellular Carcinoma in a Patient with Crohn's Disease on Azathioprine.Case reports in gastroenterologyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatocellular carcinoma most commonly occurs in patients with underlying liver disease or cirrhosis. We describe a case of hepatocellular carcinoma in a 34-year-old man with Crohn's disease treated with azathioprine and infliximab. The patient had no history of liver disease and a complete autoimmune and viral workup was unremarkable. Unfortunately, the patient developed widespread metastatic disease and passed away 5 months after his initial diagnosis. The mechanism of hepatocellular carcinoma in patients' with Crohn's disease is poorly understood and may include both autoimmunity and treatment-related complications. Previous case reports suggest the possibility of a concerning association between azathioprine therapy and the development of hepatocellular carcinoma in patients with Crohn's disease. Clinicians may consider early imaging in patients with Crohn's disease presenting with concerning symptomatology or abnormal liver enzymes, especially in those being treated with azathioprine alone or in combination with infliximab. Future research may help to uncover additional risk factors for this exceedingly rare diagnosis in this patient population.
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Registered trials
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