Evidence map›Paper›PMID 25587423›Full record

ReviewBiosensors2014

Biosensors with built-in biomolecular logic gates for practical applications.

Yu-Hsuan Lai, Sin-Cih Sun, Min-Chieh Chuang

Abstract readReview
In one paragraph

Review in Biosensors, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Advances in the application of logic gates in nanozymes.Analytical and bioanalytical chemistry · 2024
    Review
  5. Engineered Bacteria as Living Biosensors in Dermal Tattoos.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
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  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yu-Hsuan LaiDepartment of Chemistry, Tunghai University, Taichung 40704, Taiwan; E-Mails: karenlai0222@gmail.com (Y.-H.L.); sandy79325@gmail.com (S.-C.S.).
Sin-Cih SunDepartment of Chemistry, Tunghai University, Taichung 40704, Taiwan; E-Mails: karenlai0222@gmail.com (Y.-H.L.); sandy79325@gmail.com (S.-C.S.).
Min-Chieh ChuangDepartment of Chemistry, Tunghai University, Taichung 40704, Taiwan; E-Mails: karenlai0222@gmail.com (Y.-H.L.); sandy79325@gmail.com (S.-C.S.).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Molecular logic gates, designs constructed with biological and chemical molecules, have emerged as an alternative computing approach to silicon-based logic operations. These molecular computers are capable of receiving and integrating multiple stimuli of biochemical significance to generate a definitive output, opening a new research avenue to advanced diagnostics and therapeutics which demand handling of complex factors and precise control. In molecularly gated devices, Boolean logic computations can be activated by specific inputs and accurately processed via bio-recognition, bio-catalysis, and selective chemical reactions. In this review, we survey recent advances of the molecular logic approaches to practical applications of biosensors, including designs constructed with proteins, enzymes, nucleic acids, nanomaterials, and organic compounds, as well as the research avenues for future development of digitally operating "sense and act" schemes that logically process biochemical signals through networked circuits to implement intelligent control systems.

Indexed as

biomedical applicationbiosensorlogic gatemolecular computing

Identifiers

PMID25587423
PMCPMC4264359

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.