ArticleInternational journal of biomaterials2014
Ciprofloxacin release using natural rubber latex membranes as carrier.
Article in International journal of biomaterials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 62 citations in OpenAlex.
- Functionalization of magnetic nanoparticles with 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid as an efficient adsorbent for the Gefitinib removal from water.Scientific reports · 2025Article
- BCS II/IV antibiotics blended with SPEEK nanofibrous mat as an alternative for recurrent wound care: AnCurrent research in pharmacology and drug discovery · 2025Article
- Porous Deproteinized Natural Rubber Film Loaded with Silver Nanoparticles for Topical Drug Delivery.Pharmaceutics · 2023Article
- Glycerol and Antimicrobial Peptide-Modified Natural Latex for Bacteriostasis of Skin Wounds.ACS omega · 2023Article
- Drug-Eluting Rubber Bands for Tissue Ligation.ACS applied materials & interfaces · 2022Article
- Evaluation of peptides release using a natural rubber latex biomembrane as a carrier.Amino acids · 2018Article
- Recycle of Immobilized Endocellulases in Different Conditions for Cellulose Hydrolysis.Enzyme research · 2017Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural rubber latex (NRL) from Hevea brasiliensis is easily manipulated, low cost, is of can stimulate natural angiogenesis and cellular adhesion, is a biocompatible, material and presents high mechanical resistance. Ciprofloxacin (CIP) is a synthetic antibiotic (fluoroquinolone) used in the treatment of infection at external fixation screws sites and remote infections, and this use is increasingly frequent in medical practice. The aim of this study was to develop a novel sustained delivery system for CIP based on NRL membranes and to study its delivery system behavior. CIP was found to be adsorbed on the NRL membrane, according to results of energy dispersive X-ray spectroscopy. Results show that the membrane can release CIP for up to 59.08% in 312 hours and the mechanism is due to super case II (non-Fickian). The kinetics of the drug release could be fitted with double exponential function X-ray diffraction and Fourier transform infrared (FTIR) spectroscopy shows some interaction by hydrogen bound, which influences its mechanical behavior.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.