ArticleInternational journal of endocrinology2014
Serum leptin levels in polycystic ovary syndrome and its relationship with metabolic and hormonal profile in pakistani females.
Article in International journal of endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- The effectiveness of fasting regimens on serum levels of some major weight regulating hormones: a GRADE-assessed systematic review and meta-analysis in randomized controlled trial.Journal of health, population, and nutrition · 2025Pooled it
- Obesity prevalence, physical activity, and dietary practices among adults in Saudi Arabia.Frontiers in public health · 2023Article
- Obesity and Its Associations with Gender, Smoking, Consumption of Sugary Drinks, and Hour of Sleep Among King Abdulaziz University Students in Saudi Arabia.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Article
- Sam68 mediates leptin signaling and action in human granulosa cells: possible role in leptin resistance in PCOS.Endocrine connections · 2020Article
- RS1799817 in INSR associates with susceptibility to polycystic ovary syndrome.Journal of medical biochemistry · 2020Article
- Relationship of Serum Leptin and Reproductive Hormones in Unexplained Infertile and Fertile Females.Cureus · 2019Article
- A study of ghrelin and leptin levels and their relationship to metabolic profiles in obese and lean Saudi women with polycystic ovary syndrome (PCOS).Lipids in health and disease · 2018Article
- Leptin as well as Free Leptin Receptor Is Associated with Polycystic Ovary Syndrome in Young Women.International journal of endocrinology · 2015Article
- Cross talk between serum Kisspeptin-Leptin during assisted reproduction techniques.Pakistan journal of medical sciencesArticle
- Leptin and body mass index in polycystic ovary syndrome.Indian journal of endocrinology and metabolismArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study aimed to investigate the levels of serum leptin in PCOS females and to correlate it with metabolic and hormonal parameters. Sixty-two PCOS and ninety normal cycling (NC) females with matched age and body mass index (BMI) were recruited for this cross-sectional study. Serum leptin, FSH, LH, E2, free testosterone, progesterone, thyroid profile, and FBG levels were measured. The mean leptin levels in PCOS and NC were not significantly different (45.56 ng/mL ± 1.49 vs 41.78 ± 1.31 ng/mL, P > 0.05); however, leptin levels showed a strong correlation with BMI in PCOS and NC group (r = 0.77, P < 0.0001; r = 0.82, P < 0.0001, resp.). High E2 levels in NC had a significant correlation with leptin whereas FBG correlated with leptin in PCOS (r = 0.51, P = 0.005). TSH had a substantial correlation (r = 0.49, P < 0.005; r = 0.69, P < 0.005) in PCOS and NC, respectively. There was no significant difference found in circulating leptin concentration between PCOS and NC subjects. Leptin levels in PCOS were related with metabolic impairments manifested by disturbance in FBG levels and impairment of reproductive functions in terms of reduced E2 secretion.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.