Evidence map›Paper›PMID 25587243›Full record

ReviewPediatric rheumatology online journal2015

Mucocutaneous manifestations in juvenile-onset systemic lupus erythematosus: a review of literature.

Direkrit Chiewchengchol, Ruth Murphy, Steven W Edwards, Michael W Beresford

Open access · goldAbstract readReview
In one paragraph

Review in Pediatric rheumatology online journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 72 citations in OpenAlex.

  1. Article
  2. Article
  3. Systemic Lupus Erythematosus in Children.Indian journal of pediatrics · 2024
    Review
  4. Revisiting Childhood-Onset Systemic Lupus Erythematosus.Turkish archives of pediatrics · 2024
    Article
  5. Oral Lesion Management in Juvenile SLE with Hepatosplenomegaly.International medical case reports journal · 2024
    Article
  6. Article
  7. Observational
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Observational
  15. Article
  16. Article
  17. Review
  18. [Juvenile systemic lupus erythematosus with unusual manifestation of lupus-associated panniculitis].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2015
    Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Direkrit ChiewchengcholInstitute of Translational Medicine, Alder Hey Children's NHS Foundation Trust, University of Liverpool, Liverpool, UK ; Institute of Integrative Biology, University of Liverpool, Liverpool, UK ; Immunology Unit & Center of Excellence in Immunology and Immune-mediated Disease, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Ruth MurphyDepartment of Dermatology, Queens Medical Centre, Nottingham University Teaching Hospitals, Nottingham, UK.
Steven W EdwardsInstitute of Integrative Biology, University of Liverpool, Liverpool, UK.
Michael W BeresfordInstitute of Translational Medicine, Alder Hey Children's NHS Foundation Trust, University of Liverpool, Liverpool, UK ; Department of Women's and Children's Health, Institute of Translational Medicine, Alder Hey Children's NHS Foundation Trust, Eaton Road, Liverpool, L12 2AP UK.
University of Liverpool · GBNottingham University Hospitals NHS Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients diagnosed with juvenile-onset systemic lupus erythematosus (JSLE) often have skin and oral lesions as part of their presentation. These mucocutaneous lesions, as defined by the American College of Rheumatology (ACR) in 1997, include malar rash, discoid rash, photosensitivity and oral ulcers. It is therefore essential to recognize mucocutaneous lesions to accurately diagnose JSLE. The mucocutaneous lesions can be divided into those with classical histological features (LE specific) and those strongly associated with and forming part of the diagnostic spectrum, but without the classical histological changes of lupus (LE nonspecific). A malar rash is the most commonly associated LE specific dermatological presentation. This skin manifestation is an acute form and also correlates with disease activity. Subacute (polycyclic or papulosquamous lesions) and chronic (discoid lesions) forms, whilst showing classical histological changes supportive of lupus, are less commonly associated with systemic lupus and do not correlate with disease activity. The most commonly associated skin lesions without classical lupus changes are cutaneous vasculitis, oral ulcers and diffuse non-scarring alopecia. These signs frequently relate to disease activity. An understanding of cutaneous signs and symptoms of lupus in children is important to avoid delay in diagnosis. They will often improve as lupus is adequately controlled and their reappearance is often the first indicator of a disease flare.

Indexed as

Age of OnsetChildDelayed DiagnosisDiagnosis, DifferentialHumansLupus Erythematosus, SystemicMouth DiseasesMouth MucosaSkinSkin DiseasesDiagnosisJuvenile-onset systemic lupus erythematosusLupus erythematosus nonspecific lesionsLupus erythematosus specific lesionsMucocutaneous lupus lesionsTreatment

Identifiers

PMID25587243
PMCPMC4292833
OpenAlexW2157490585

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.