ArticleMediators of inflammation2014
Brain-derived neurotrophic factor in chronic periodontitis.
Article in Mediators of inflammation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Evaluation of salivary BDNF levels in gingivitis and periodontitis: a preliminary research.BMC oral health · 2025Article
- Perio-dontal - Neuro-immune axis: Expression analysis of Vitamin D and brain-derived neurotrophic factor in periodontitis patients with neuro-psychiatric disorders.Bioinformation · 2025Article
- Dynamic changes in macrophage polarization during the resolution phase of periodontal disease.Immunity, inflammation and disease · 2024Article
- Expression Pattern and Value of Brain-Derived Neurotrophic Factor in Periodontitis.International dental journal · 2023Article
- Mental health and periodontal and peri-implant diseases.Periodontology 2000 · 2022Review
- Metagenomic Analysis Reveals a Mitigating Role forNutrients · 2022Article
- The Complex Molecular Picture of Gut and Oral Microbiota-Brain-Depression System: What We Know and What We Need to Know.Frontiers in psychiatry · 2021Review
- Identification of Potential Candidate Genes of Oral Cancer in Response to Chronic Infection WithFrontiers in oncology · 2019Article
- Depression and Inflammatory Periodontal Disease Considerations-An Interdisciplinary Approach.Frontiers in psychology · 2016Article
- Hippocampal BDNF content in response to short- and long-term exercise.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2015Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophic factor family. Outside the nervous system, BDNF has been shown to be expressed in various nonneural tissues, such as periodontal ligament, dental pulp, and odontoblasts. Although a role for BDNF in periodontal regeneration has been suggested, a function for BDNF in periodontal disease has not yet been studied. The aim of this study was to analyze the BDNF levels in periodontal tissues of patients with chronic periodontitis (CP) and periodontally healthy controls (HC). All subjects were genotyped for the rs4923463 and rs6265 BDNF polymorphisms. Periodontal tissues were collected for ELISA, myeloperoxidase (MPO), and microscopic analysis from 28 CP patients and 29 HC subjects. BDNF levels were increased in CP patients compared to HC subjects. A negative correlation was observed when analyzing concentration of BDNF and IL-10 in inflamed periodontium. No differences in frequencies of BDNF genotypes between CP and HC subjects were observed. However, BDNF genotype GG was associated with increased levels of BDNF, TNF-α, and CXCL10 in CP patients. In conclusion, BDNF seems to be associated with periodontal disease process, but the specific role of BDNF still needs to be clarified.
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