ArticleAmerican journal of physiology. Renal physiology2015
Shear stress is normalized in glomerular capillaries following ⅚ nephrectomy.
Article in American journal of physiology. Renal physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 25 citations in OpenAlex.
- Cardiac mechanotransduction from development to disease.APL bioengineering · 2026Review
- Renal microcirculation and mechanisms in diabetic kidney disease.Frontiers in endocrinology · 2025Review
- Photoplethysmography for Assessing Microcirculation in Hypertensive Patients After Taking Antihypertensive Drugs: A Review.Journal of multidisciplinary healthcare · 2024Review
- Kidney-on-a-Chip: Mechanical Stimulation and Sensor Integration.Sensors (Basel, Switzerland) · 2022Review
- Single nephron glomerular filtration rate measured by linescan multiphoton microscopy compared to conventional micropuncture.Pflugers Archiv : European journal of physiology · 2022Article
- Intravital Multiphoton Microscopy as a Tool for Studying Renal Physiology, Pathophysiology and Therapeutics.Frontiers in physiology · 2022Review
- Vascularized Microfluidics and Their Untapped Potential for Discovery in Diseases of the Microvasculature.Annual review of biomedical engineering · 2021Review
- The Indiana O'Brien Center for Advanced Renal Microscopic Analysis.American journal of physiology. Renal physiology · 2021Review
- Simulations of Glomerular Shear and Hoop Stresses in Diabetes, Hypertension, and Reduced Renal Mass using a Network Model of a Rat Glomerulus.Physiological reports · 2020Article
- Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis.Journal of the American Society of Nephrology : JASN · 2020Article
- A mathematical model to predict nanomedicine pharmacokinetics and tumor delivery.Computational and structural biotechnology journal · 2020Article
- Fluorescent Imaging and Microscopy for Dynamic Processes in Rats.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Mechanical challenges and cytoskeletal impairments in focal segmental glomerulosclerosis.American journal of physiology. Renal physiology · 2018Review
- Disease-causing mutation in α-actinin-4 promotes podocyte detachment through maladaptation to periodic stretch.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Live-Animal Imaging of Renal Function by Multiphoton Microscopy.Current protocols in cytometry · 2018Article
- Intravital multiphoton microscopy as a tool for studying renal physiology and pathophysiology.Methods (San Diego, Calif.) · 2017Review
- Surgical preparation of rats and mice for intravital microscopic imaging of abdominal organs.Methods (San Diego, Calif.) · 2017Article
- Imaging the pharmacology of nanomaterials by intravital microscopy: Toward understanding their biological behavior.Advanced drug delivery reviews · 2017Review
- A Two-Criterion Model for Microvascular Bio-Effects Induced In Vivo by Contrast Microbubbles Exposed to Medical Ultrasound.Ultrasound in medicine & biology · 2016Article
- Intravital imaging in the kidney.Current opinion in nephrology and hypertension · 2016Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Loss of significant functional renal mass results in compensatory structural and hemodynamic adaptations in the nephron. While these changes have been characterized in several injury models, how they affect hemodynamic forces at the glomerular capillary wall has not been adequately characterized, despite their potential physiological significance. Therefore, we used intravital multiphoton microscopy to measure the velocity of red blood cells in individual glomerular capillaries of normal rats and rats subjected to ⅚ nephrectomy. Glomerular capillary blood flow rate and wall shear stress were then estimated using previously established experimental and mathematical models to account for changes in hematocrit and blood rheology in small vessels. We found little change in the hemodynamic parameters in glomerular capillaries immediately following injury. At 2 wk postnephrectomy, significant changes in individual capillary blood flow velocity and volume flow rate were present. Despite these changes, estimated capillary wall shear stress was unchanged. This was a result of an increase in capillary diameter and changes in capillary blood rheology in nephrectomized rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.