Evidence map›Paper›PMID 25587109›Full record

ReviewCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2015

An epidemiologic review of marijuana and cancer: an update.

Yu-Hui Jenny Huang, Zuo-Feng Zhang, Donald P Tashkin, Bingjian Feng, Kurt Straif, Mia Hashibe

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06381180 (Wayne Warrior CAnnabis Research and Education), which is not on this map. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
14.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06381180 phase1 / phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Wayne Warrior CAnnabis Research and Education: Cannabis and Behavioral Health

TypeinterventionalSponsorWayne State UniversityRan2025 to 2030Enrolled500ConditionsPost Traumatic Stress Disorder, Cannabis Use, Suicide, VeteransArmsTetrahydrocannabinol, Cannabidiol, Placebo
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 104 citations in OpenAlex.

  1. Scoping Review and Meta-Analysis Suggests thatCannabis and cannabinoid research · 2021
    Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Genotoxicity study ofToxicology reports · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Use of cannabis in urological cancer patients: A review to evaluate risk for cancer development, therapeutic use, and symptom management.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2021
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Genotoxicity of Marijuana in Mono-Users.Frontiers in psychiatry · 2021
    Article
  18. Hookah and Electronic Inhalant Device Use and Perceptions Among African American Youth and Young Adults: Are We Asking the Right Questions?Health education & behavior : the official publication of the Society for Public Health Education · 2020
    Article
  19. Cannabinoids Promote Progression of HPV-Positive Head and Neck Squamous Cell Carcinoma via p38 MAPK Activation.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yu-Hui Jenny HuangDivision of Public Health, Department of Family and Preventive Medicine, and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah.
Zuo-Feng ZhangDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California.
Donald P TashkinDavid Geffen School of Medicine at UCLA, Los Angeles, California.
Bingjian FengDepartment of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah.
Kurt StraifInternational Agency for Research on Cancer, Lyon, France.
Mia HashibeDivision of Public Health, Department of Family and Preventive Medicine, and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah. mia.hashibe@utah.edu.
Centre International de Recherche sur le Cancer · FR

Funding

UCLA CANCER EPIDEMIOLOGY TRAINING PROGRAMT32CA009142 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, ZUO-FENG · 1986 to 2024
$6.3M
Exome sequencing for head and neck cancer susceptibility genesR01DE023414 · NIDCR · UNIVERSITY OF UTAH · PI HASHIBE, MIA, TAVTIGIAN, SEAN VAHRAM · 2014 to 2018
$3.6M
Head and Neck Cancer Risk Prediction ModelR21CA158848 · NCI · UNIVERSITY OF UTAH · PI HASHIBE, MIA, LEE, YUAN CHIN AMY · 2012 to 2013
$346k
NCI NIH HHS R21 CA158848NCI NIH HHS T32 CA009142NIDCR NIH HHS R01 DE023414World Health Organization 001
6 · The paper itself

Abstract

Marijuana use is legal in two states and additional states are considering legalization. Approximately 18 million Americans are current marijuana users. There is currently no consensus on whether marijuana use is associated with cancer risk. Our objective is to review the epidemiologic studies on this possible association. We identified 34 epidemiologic studies on upper aerodigestive tract cancers (n = 11), lung cancer (n = 6), testicular cancer (n = 3), childhood cancers (n = 6), all cancers (n = 1), anal cancer (n = 1), penile cancer (n = 1), non-Hodgkin lymphoma (n = 2), malignant primary gliomas (n = 1), bladder cancer (n = 1), and Kaposi sarcoma (n = 1). Studies on head and neck cancer reported increased and decreased risks, possibly because there is no association, or because risks differ by human papillomavirus status or geographic differences. The lung cancer studies largely appear not to support an association with marijuana use, possibly because of the smaller amounts of marijuana regularly smoked compared with tobacco. Three testicular cancer case-control studies reported increased risks with marijuana use [summary ORs, 1.56; 95% confidence interval (CI), 1.09-2.23 for higher frequency and 1.50 (95% CI, 1.08-2.09) for ≥10 years]. For other cancer sites, there is still insufficient data to make any conclusions. Considering that marijuana use may change due to legalization, well-designed studies on marijuana use and cancer are warranted.

Indexed as

HumansMarijuana SmokingNeoplasmsRisk Factors

Identifiers

PMID25587109
PMCPMC4302404
OpenAlexW2124065840

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.