ArticleCirculation. Heart failure2015
Cellular postconditioning: allogeneic cardiosphere-derived cells reduce infarct size and attenuate microvascular obstruction when administered after reperfusion in pigs with acute myocardial infarction.
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In one paragraph
Article in Circulation. Heart failure, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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55citing papers in PubMed, 1 pooled it
10.0field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Cardiac repair after myocardial infarction: A two-sided role of inflammation-mediated.Frontiers in cardiovascular medicine · 2022Pooled it
- Cardiosphere-Derived Cells from Not Dilated and Dilated Human Myocardium Exhibit Enhanced Metabolic Potential Compared with Conventional Cardiac Mesenchymal Stem/Stromal Cells.International journal of molecular sciences · 2026Article
- Bioengineered Cellular and Acellular Therapies for Ischemic Heart Disease in Clinically Relevant Models.Bioengineering (Basel, Switzerland) · 2026Review
- Advances in Pathophysiology and Novel Therapeutic Strategies for Coronary No-Reflow Phenomenon.Biomedicines · 2025Review
- Review
- Cardiac progenitor cell therapy: mechanisms of action.Cell & bioscience · 2024Review
- Three-vessel coronary infusion of cardiosphere-derived cells for the treatment of heart failure with preserved ejection fraction in a pre-clinical pig model.Basic research in cardiology · 2023Article
- Widespread intracoronary allogeneic cardiosphere-derived cell therapy with and without cyclosporine in reperfused myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2022Article
- Efficacy of Stem Cell Therapy in Large Animal Models of Ischemic Cardiomyopathies: A Systematic Review and Meta-Analysis.Animals : an open access journal from MDPI · 2022Review
- The epicardial delivery of cardiosphere derived cells or their extracellular vesicles is safe but of limited value in experimental infarction.Scientific reports · 2021Article
- Neutrophils aid cellular therapeutics by enhancing glycoengineered stem cell recruitment and retention at sites of inflammation.Biomaterials · 2021Article
- Mechanistic and therapeutic distinctions between cardiosphere-derived cell and mesenchymal stem cell extracellular vesicle non-coding RNA.Scientific reports · 2021Article
- Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease.Cells · 2021Review
- Review
- Quantitative Hybrid Cardiac [Molecular therapy. Methods & clinical development · 2020Article
- The Intrapericardial Delivery of Extracellular Vesicles from Cardiosphere-Derived Cells Stimulates M2 Polarization during the Acute Phase of Porcine Myocardial Infarction.Stem cell reviews and reports · 2020Article
- Heart regeneration in mouse and human: A bioengineering perspective.Current opinion in physiology · 2020Article
- Cortical Bone Derived Stem Cells Modulate Cardiac Fibroblast Response via miR-18a in the Heart After Injury.Frontiers in cell and developmental biology · 2020Article
- Macrophages in cardiac repair: Environmental cues and therapeutic strategies.Experimental & molecular medicine · 2019Review
- Role of cardiac progenitor cell-derived exosome-mediated microRNA-210 in cardiovascular disease.Journal of cellular and molecular medicine · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 3 institutions in 2 countries.
Hideaki KanazawaFrom the Cedars-Sinai Heart Institute, Los Angeles, CA (H.K., E.T., K.M., K.Y., J.F.D., G.D.C., R.R.S., J.S., R.C.M., R.G., D.L., S.C., R.R.M., L.M., E.M.); Capricor Inc, Los Angeles, CA (R.R.S., M.K., I.V., L.M.); Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (H.K., K.F.); Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh (K.C.); and Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh (K.C.).
Eleni TseliouFrom the Cedars-Sinai Heart Institute, Los Angeles, CA (H.K., E.T., K.M., K.Y., J.F.D., G.D.C., R.R.S., J.S., R.C.M., R.G., D.L., S.C., R.R.M., L.M., E.M.); Capricor Inc, Los Angeles, CA (R.R.S., M.K., I.V., L.M.); Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (H.K., K.F.); Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh (K.C.); and Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh (K.C.).
Konstantinos MalliarasFrom the Cedars-Sinai Heart Institute, Los Angeles, CA (H.K., E.T., K.M., K.Y., J.F.D., G.D.C., R.R.S., J.S., R.C.M., R.G., D.L., S.C., R.R.M., L.M., E.M.); Capricor Inc, Los Angeles, CA (R.R.S., M.K., I.V., L.M.); Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (H.K., K.F.); Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh (K.C.); and Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh (K.C.).
Kristine YeeFrom the Cedars-Sinai Heart Institute, Los Angeles, CA (H.K., E.T., K.M., K.Y., J.F.D., G.D.C., R.R.S., J.S., R.C.M., R.G., D.L., S.C., R.R.M., L.M., E.M.); Capricor Inc, Los Angeles, CA (R.R.S., M.K., I.V., L.M.); Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (H.K., K.F.); Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh (K.C.); and Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh (K.C.).
James F DawkinsFrom the Cedars-Sinai Heart Institute, Los Angeles, CA (H.K., E.T., K.M., K.Y., J.F.D., G.D.C., R.R.S., J.S., R.C.M., R.G., D.L., S.C., R.R.M., L.M., E.M.); Capricor Inc, Los Angeles, CA (R.R.S., M.K., I.V., L.M.); Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (H.K., K.F.); Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh (K.C.); and Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh (K.C.).
Geoffrey De CoutoFrom the Cedars-Sinai Heart Institute, Los Angeles, CA (H.K., E.T., K.M., K.Y., J.F.D., G.D.C., R.R.S., J.S., R.C.M., R.G., D.L., S.C., R.R.M., L.M., E.M.); Capricor Inc, Los Angeles, CA (R.R.S., M.K., I.V., L.M.); Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (H.K., K.F.); Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh (K.C.); and Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh (K.C.).
Rachel R SmithFrom the Cedars-Sinai Heart Institute, Los Angeles, CA (H.K., E.T., K.M., K.Y., J.F.D., G.D.C., R.R.S., J.S., R.C.M., R.G., D.L., S.C., R.R.M., L.M., E.M.); Capricor Inc, Los Angeles, CA (R.R.S., M.K., I.V., L.M.); Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (H.K., K.F.); Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh (K.C.); and Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh (K.C.).
Michelle KrekeFrom the Cedars-Sinai Heart Institute, Los Angeles, CA (H.K., E.T., K.M., K.Y., J.F.D., G.D.C., R.R.S., J.S., R.C.M., R.G., D.L., S.C., R.R.M., L.M., E.M.); Capricor Inc, Los Angeles, CA (R.R.S., M.K., I.V., L.M.); Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (H.K., K.F.); Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh (K.C.); and Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh (K.C.).
Jeffrey SeinfeldFrom the Cedars-Sinai Heart Institute, Los Angeles, CA (H.K., E.T., K.M., K.Y., J.F.D., G.D.C., R.R.S., J.S., R.C.M., R.G., D.L., S.C., R.R.M., L.M., E.M.); Capricor Inc, Los Angeles, CA (R.R.S., M.K., I.V., L.M.); Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (H.K., K.F.); Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh (K.C.); and Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh (K.C.).
Ryan C MiddletonFrom the Cedars-Sinai Heart Institute, Los Angeles, CA (H.K., E.T., K.M., K.Y., J.F.D., G.D.C., R.R.S., J.S., R.C.M., R.G., D.L., S.C., R.R.M., L.M., E.M.); Capricor Inc, Los Angeles, CA (R.R.S., M.K., I.V., L.M.); Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (H.K., K.F.); Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh (K.C.); and Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh (K.C.).
Romain GalletFrom the Cedars-Sinai Heart Institute, Los Angeles, CA (H.K., E.T., K.M., K.Y., J.F.D., G.D.C., R.R.S., J.S., R.C.M., R.G., D.L., S.C., R.R.M., L.M., E.M.); Capricor Inc, Los Angeles, CA (R.R.S., M.K., I.V., L.M.); Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (H.K., K.F.); Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh (K.C.); and Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh (K.C.).
Ke ChengFrom the Cedars-Sinai Heart Institute, Los Angeles, CA (H.K., E.T., K.M., K.Y., J.F.D., G.D.C., R.R.S., J.S., R.C.M., R.G., D.L., S.C., R.R.M., L.M., E.M.); Capricor Inc, Los Angeles, CA (R.R.S., M.K., I.V., L.M.); Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (H.K., K.F.); Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh (K.C.); and Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh (K.C.).
Daniel LuthringerFrom the Cedars-Sinai Heart Institute, Los Angeles, CA (H.K., E.T., K.M., K.Y., J.F.D., G.D.C., R.R.S., J.S., R.C.M., R.G., D.L., S.C., R.R.M., L.M., E.M.); Capricor Inc, Los Angeles, CA (R.R.S., M.K., I.V., L.M.); Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (H.K., K.F.); Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh (K.C.); and Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh (K.C.).
Ileana ValleFrom the Cedars-Sinai Heart Institute, Los Angeles, CA (H.K., E.T., K.M., K.Y., J.F.D., G.D.C., R.R.S., J.S., R.C.M., R.G., D.L., S.C., R.R.M., L.M., E.M.); Capricor Inc, Los Angeles, CA (R.R.S., M.K., I.V., L.M.); Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (H.K., K.F.); Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh (K.C.); and Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh (K.C.).
Supurna ChowdhuryFrom the Cedars-Sinai Heart Institute, Los Angeles, CA (H.K., E.T., K.M., K.Y., J.F.D., G.D.C., R.R.S., J.S., R.C.M., R.G., D.L., S.C., R.R.M., L.M., E.M.); Capricor Inc, Los Angeles, CA (R.R.S., M.K., I.V., L.M.); Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (H.K., K.F.); Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh (K.C.); and Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh (K.C.).
Keiichi FukudaFrom the Cedars-Sinai Heart Institute, Los Angeles, CA (H.K., E.T., K.M., K.Y., J.F.D., G.D.C., R.R.S., J.S., R.C.M., R.G., D.L., S.C., R.R.M., L.M., E.M.); Capricor Inc, Los Angeles, CA (R.R.S., M.K., I.V., L.M.); Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (H.K., K.F.); Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh (K.C.); and Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh (K.C.).
Raj R MakkarFrom the Cedars-Sinai Heart Institute, Los Angeles, CA (H.K., E.T., K.M., K.Y., J.F.D., G.D.C., R.R.S., J.S., R.C.M., R.G., D.L., S.C., R.R.M., L.M., E.M.); Capricor Inc, Los Angeles, CA (R.R.S., M.K., I.V., L.M.); Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (H.K., K.F.); Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh (K.C.); and Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh (K.C.).
Linda MarbánFrom the Cedars-Sinai Heart Institute, Los Angeles, CA (H.K., E.T., K.M., K.Y., J.F.D., G.D.C., R.R.S., J.S., R.C.M., R.G., D.L., S.C., R.R.M., L.M., E.M.); Capricor Inc, Los Angeles, CA (R.R.S., M.K., I.V., L.M.); Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (H.K., K.F.); Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh (K.C.); and Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh (K.C.).
Eduardo MarbánFrom the Cedars-Sinai Heart Institute, Los Angeles, CA (H.K., E.T., K.M., K.Y., J.F.D., G.D.C., R.R.S., J.S., R.C.M., R.G., D.L., S.C., R.R.M., L.M., E.M.); Capricor Inc, Los Angeles, CA (R.R.S., M.K., I.V., L.M.); Department of Cardiology, Keio University School of Medicine, Tokyo, Japan (H.K., K.F.); Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh (K.C.); and Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh (K.C.). eduardo.marban@csmc.edu.
Keio University · JPCapricor Therapeutics (United States) · USNorth Carolina State University · US
Funding
Training in Advanced Heart Disease ResearchT32HL116273 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI Joshua I Goldhaber, EDUARDO MARBAN · 2013 to 2026
$5.6MSafety and Efficacy of Allogeneic Cardiosphere-derived Stem Cells After MIRC3HL103356 · NHLBI · CAPRICOR, INC. · PI MARBAN, LINDA, SMITH, RACHEL RUCKDESCHEL · 2010 to 2010
$3.0MNHLBI NIH HHS HL103356NHLBI NIH HHS RC3 HL103356NHLBI NIH HHS T32 HL116273
Abstract
backgroundIntracoronary delivery of cardiosphere-derived cells (CDCs) has been demonstrated to be safe and effective in porcine and human chronic myocardial infarction. However, intracoronary delivery of CDCs after reperfusion in acute myocardial infarction has never been assessed in a clinically-relevant large animal model. We tested CDCs as adjunctive therapy to reperfusion in a porcine model of myocardial infarction. METHODS AND
resultsFirst, escalating doses (5, 7.5, and 10 million cells) of allogeneic CDCs were administered intracoronary 30 minutes after reperfusion. Forty-eight hours later, left ventriculography was performed and animals euthanized to measure area at risk, infarct size (IS), and microvascular obstruction. Second, identical end points were measured in a pivotal study of minipigs (n=14) that received 8.5 to 9 million allogeneic CDCs, placebo solution, or sham. Multiple indicators of cardioprotection were observed with 7.5 and 10 million allogeneic CDCs, but not 5 million CDCs, relative to control. In the pivotal study, IS, microvascular obstruction, cardiomyocyte apoptosis, and adverse left ventricular remodeling were all smaller in the CDC group than in sham or placebo groups. In addition, serum troponin I level at 24 hours was lower after CDC infusion than that in the placebo or sham groups, consistent with the histologically-demonstrated reduction in IS.
conclusionsIntracoronary delivery of allogeneic CDCs is safe, feasible, and effective in cardioprotection, reducing IS, preventing microvascular obstruction, and attenuating adverse acute remodeling. This novel cardioprotective effect, which we call cellular postconditioning, differs from previous strategies to reduce IS in that it works even when initiated with significant delay after reflow.
Indexed as
Myocardial ReperfusionAnimalsCoronary VesselsDisease Models, AnimalHeart FailureInjections, Intra-ArterialIschemic PostconditioningMyocardial InfarctionStem Cell TransplantationSwineSwine, MiniatureTransplantation, HomologousVentricular Remodelingacute myocardial infarctionanimal modelscoronary interventionsischemic postconditioning
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