ArticleMolecular medicine reports2015
Upregulation of miR-142-5p in atherosclerotic plaques and regulation of oxidized low-density lipoprotein-induced apoptosis in macrophages.
Article in Molecular medicine reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- The Effect of Physical Activity/Exercise on miRNA Expression and Function in Non-Communicable Diseases-A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Changes in miRNA expression in patients with peripheral arterial vascular disease during moderate- and vigorous-intensity physical activity.European journal of applied physiology · 2023Trial
- Effects of single bouts of different endurance exercises with different intensities on microRNA biomarkers with and without blood flow restriction: a three-arm, randomized crossover trial.European journal of applied physiology · 2021Trial
- MicroRNAs as master regulators of macrophage function in atherosclerosis: From polarization to therapeutic potential.iScience · 2026Review
- The Role of Extracellular Non-coding RNAs in Atherosclerosis.Journal of cardiovascular translational research · 2022Review
- A Potential Target for Diabetic Vascular Damage: High Glucose-Induced Monocyte Extracellular Vesicles Impair Endothelial Cells by Delivering miR-142-5p.Frontiers in bioengineering and biotechnology · 2022Article
- Construction and Bioinformatics Analysis of circRNA-miRNA-mRNA Network in Acute Myocardial Infarction.Frontiers in genetics · 2022Article
- Regulating COX10-AS1 / miR-142-5p / PAICS axis inhibits the proliferation of non-small cell lung cancer.Bioengineered · 2021Article
- Berberine Attenuates MPPNeurochemical research · 2021Article
- Circulating level of microRNA-142-5p is a potential biomarker for predicting in-stent restenosis: a case-control study.BMC cardiovascular disorders · 2021Article
- Pathological Crosstalk Between Oxidized LDL and ER Stress in Human Diseases: A Comprehensive Review.Frontiers in cell and developmental biology · 2021Review
- Increased miR-142 Levels in Plasma and Atherosclerotic Plaques from Peripheral Artery Disease Patients with Post-Surgery Cardiovascular Events.International journal of molecular sciences · 2020Article
- Serum miRNA-142 and BMP-2 are markers of recovery following hip replacement surgery for femoral neck fracture.Experimental and therapeutic medicine · 2020Article
- High level of circulating microRNA-142 is associated with acute myocardial infarction and reduced survival.Irish journal of medical science · 2020Article
- Downregulation of miR‑142‑5p inhibits human aortic smooth muscle cell proliferation and migration by targeting MKL2.Molecular medicine reports · 2020Article
- Circulating Exosomal miRNAs as Novel Biomarkers for Stable Coronary Artery Disease.BioMed research international · 2020Article
- Plasma miR-142 predicts major adverse cardiovascular events as an intermediate biomarker of dual antiplatelet therapy.Acta pharmacologica Sinica · 2019Article
- miR-142-5p suppresses proliferation and promotes apoptosis of human osteosarcoma cell line, HOS, by targeting PLA2G16 through the ERK1/2 signaling pathway.Oncology letters · 2019Article
- Presymptomatic change in microRNAs modulates Tau pathology.Scientific reports · 2018Article
- MicroRNA‑142‑5p modulates breast cancer cell proliferation and apoptosis by targeting phosphatase and tensin homolog.Molecular medicine reports · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNA (miR)‑142‑5p is a member of the miR‑142 family, which have been shown to be associated with tumors, stem cells and disorders of the immune system. However, the role of miR‑142‑5p in atherosclerosis has yet to be investigated. In the present study, an atherosclerotic apolipoprotein E‑deficient (apoE‑/‑) mouse model was constructed and fed a high‑fat diet. The expression levels of miR‑142‑5p in the murine atherosclerotic plaques were detected by gene microarray analysis. In addition, an in vitro assay was used to determine the expression levels of miR‑142‑5p in human endothelial cells, smooth muscle cells and macrophages, which were treated with oxidized low‑density lipoprotein (ox‑LDL). Furthermore, a miR‑142‑5p inhibitor and mimic was transfected into cultured human macrophages, in order to observe the effects on transforming growth factor‑β2 (TGF‑β2) expression. The effects of co‑transfection of the miR‑142‑5p inhibitor or mimic with TGF‑β2, in human macrophages, on the rate of apoptosis was analyzed. The expression levels of miR‑142‑5p were 6.84‑fold higher in mice with stable atherosclerotic plaques, and 2.69‑fold higher in mice with vulnerable atherosclerotic plaques, as compared with the controls. Furthermore, the expression levels of miR‑142‑5p were upregulated in the cultured human macrophages. The percentage of apoptotic cells was lowest in the macrophages transfected with both TGF‑β2 and miR‑142‑5p inhibitors and treated with ox‑LDL. The expression levels of miR‑142‑5p were upregulated in the atherosclerotic plaques of the apoE‑/‑ mice. The findings of the present study have shown that the upregulation of miR‑142‑5p expression may regulate apoptosis in human macrophages by targeting TGF‑β2. This effect may have an important role in the progression of atherosclerosis.
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