ReviewParasites & vectors2015
Cellulose degradation: a therapeutic strategy in the improved treatment of Acanthamoeba infections.
Review in Parasites & vectors, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Article
- From Waste to Wealth: Unlocking the Potential of Cellulase Characteristics for Food Processing Waste Management.Foods (Basel, Switzerland) · 2025Review
- Effects of field conditions on the degradation of cellulose-based and PLA nonwoven mulches.Scientific reports · 2025Article
- Encystment and Excystment Processes inPathogens (Basel, Switzerland) · 2025Review
- Predictive reducing sugar release from lignocellulosic biomass using sequential acid pretreatment and enzymatic hydrolysis by harnessing a machine learning approach.Computational and structural biotechnology journal · 2025Article
- Evaluation of Cellulase, Pectinase, and Hemicellulase Effectiveness in Extraction of Phenolic Compounds from Grape Pomace.International journal of molecular sciences · 2024Article
- Microbial communities and their role in enhancing hemp fiber quality through field retting.Applied microbiology and biotechnology · 2024Review
- Cellulolytic characterization of the rumen-isolatedEngineering microbiology · 2024Article
- Chitosan nanoparticles improve the effectivity of miltefosine against Acanthamoeba.PLoS neglected tropical diseases · 2024Article
- Enzymatic degradation of cellulose in soil: A review.Heliyon · 2024Article
- Biological characteristics and pathogenicity ofFrontiers in microbiology · 2023Review
- A road map on synthetic strategies and applications of biodegradable polymers.Polymer bulletin (Berlin, Germany) · 2022Review
- Pythium insidiosum Keratitis: Past, Present, and Future.Ophthalmology and therapy · 2022Review
- Article
- Stable Cellulose Nanofibril Microcapsules from Pickering Emulsion Templates.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- Stimulation ofFrontiers in cell and developmental biology · 2022Article
- Valorization of Brewer's Spent Grain Using Biological Treatments and its Application in Feeds for European Seabass (Frontiers in bioengineering and biotechnology · 2022Article
- Discovery of novel carbohydrate degrading enzymes from soda lakes through functional metagenomics.Frontiers in microbiology · 2022Article
- Article
- Degradation Behavior of Polymers Used as Coating Materials for Drug Delivery-A Basic Review.Polymers · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acanthamoeba is an opportunistic free-living amoeba that can cause blinding keratitis and fatal brain infection. Early diagnosis, followed by aggressive treatment is a pre-requisite in the successful treatment but even then the prognosis remains poor. A major drawback during the course of treatment is the ability of the amoeba to enclose itself within a shell (a process known as encystment), making it resistant to chemotherapeutic agents. As the cyst wall is partly made of cellulose, thus cellulose degradation offers a potential therapeutic strategy in the effective targeting of trophozoite encased within the cyst walls. Here, we present a comprehensive report on the structure of cellulose and cellulases, as well as known cellulose degradation mechanisms with an eye to target the Acanthamoeba cyst wall. The disruption of the cyst wall will make amoeba (concealed within) susceptible to chemotherapeutic agents, and at the very least inhibition of the excystment process will impede infection recurrence, as we bring these promising drug targets into focus so that they can be explored to their fullest.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.