ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2015
Phenotypic flexibility of skeletal muscle and heart masses and expression of myostatin and tolloid-like proteinases in migrating passerine birds.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Histomorphometric plasticity in pectoral muscles and adipose tissue of Redheaded Bunting in response to skeleton photoperiod.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- Migratory lifestyle carries no added overall energy cost in a partial migratory songbird.Nature ecology & evolution · 2024Article
- Skeletal muscle and metabolic flexibility in response to changing energy demands in wild birds.Frontiers in physiology · 2022Review
- Temperature affects liver and muscle metabolism in photostimulated migratory redheaded buntings (Emberiza bruniceps).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2019Article
- PPAR expression, muscle size and metabolic rates across the gray catbird's annual cycle are greatest in preparation for fall migration.The Journal of experimental biology · 2019Article
- Context-dependent regulation of pectoralis myostatin and lipid transporters by temperature and photoperiod in dark-eyed juncos.Current zoology · 2018Article
- Differential gene expression in seasonal sympatry: mechanisms involved in diverging life histories.Biology letters · 2016Article
- Conservation physiology of animal migration.Conservation physiology · 2016Article
- Migration-induced variation of fatty acid transporters and cellular metabolic intensity in passerine birds.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2015Article
- Cross-training in birds: cold and exercise training produce similar changes in maximal metabolic output, muscle masses and myostatin expression in house sparrows (Passer domesticus).The Journal of experimental biology · 2015Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Migrant birds require large flight muscles and hearts to enhance aerobic capacity and support sustained flight. A potential mechanism for increasing muscle and heart masses during migration in birds is the muscle growth inhibitor myostatin and its metalloproteinase activators, tolloid-like proteinases (TLL-1 and TLL-2). We hypothesized that myostatin, TLL-1 and TLL-2 are downregulated during migration in pectoralis and hearts of migratory passerines to promote hypertrophy. We measured seasonal variation of tissue masses, mRNA expression of myostatin, TLL-1, and TLL-2, and myostatin protein levels in pectoralis muscle and heart for yellow warblers (Setophaga petechia), warbling vireos (Vireo gilvus), and yellow-rumped warblers (Setophaga coronata). Pectoralis mass was greatest in spring for warbling vireos and yellow warblers, but was stable between spring and fall for yellow-rumped warblers. Heart mass was higher in spring than in fall for yellow-rumped warblers, lowest in fall for warbling vireos, and seasonally stable for yellow warblers. Pectoralis and heart mRNA expression of myostatin and the TLLs did not differ significantly for any of the three species, offering little support for our hypothesis for a prominent role for myostatin in regulating migration-induced variation in pectoralis and heart masses. In contrast, pectoralis myostatin protein levels were lowest in spring for all three species, consistent with our hypothesis. Myostatin protein levels in heart, however, were seasonally stable for warbling vireos and yellow warblers, and increased in spring relative to fall for yellow-rumped warblers. These data offer mixed support for our hypothesis for the pectoralis, but suggest that myostatin is not a prominent regulator of migration-induced heart hypertrophy. Moreover, the different seasonal patterns for pectoralis mRNA and protein expression suggest that post-transcriptional modification of myostatin may contribute to pectoralis mass regulation during migration.
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