ArticleHeredity2015
Quantifying realized inbreeding in wild and captive animal populations.
Article in Heredity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 61 citations in OpenAlex.
- Article
- A Dominant Founder Lineage Has Possible Fitness Costs for the Endangered Mexican Grey Wolf.Molecular ecology · 2026Article
- Genome-wide SNP data reveal genetic relatedness and structure in an ex-situ population of threatened Fea's muntjac (ZooKeys · 2026Article
- Fine-scale assessment of ROH patterns and genomic inbreeding in diverse horse breeds using two SNP array densities.BMC veterinary research · 2025Article
- Evolution of Large Polymorphic Inversions in a Panmictic Songbird.Molecular biology and evolution · 2025Article
- Runs of Homozygosity and Inferences in Wild Populations.Molecular ecology · 2025Review
- Female chimpanzees avoid inbreeding even in the presence of substantial bisexual philopatry.Royal Society open science · 2024Article
- Genetic management on the brink of extinction: sequencing microsatellites does not improve estimates of inbreeding in wild and captive Vancouver Island marmots (Conservation genetics (Print) · 2022Article
- Genomic signatures of inbreeding in a critically endangered parrot, the kākāpō.G3 (Bethesda, Md.) · 2021Article
- Article
- A test for meiotic drive in hybrids between Australian and Timor zebra finches.Ecology and evolution · 2020Article
- A comparison of pedigree, genetic and genomic estimates of relatedness for informing pairing decisions in two critically endangered birds: Implications for conservation breeding programmes worldwide.Evolutionary applications · 2020Article
- Article
- Nonequivalent lethal equivalents: Models and inbreeding metrics for unbiased estimation of inbreeding load.Evolutionary applications · 2019Article
- Pedigree-based inbreeding coefficient explains more variation in fitness than heterozygosity at 160 microsatellites in a wild bird population.Proceedings. Biological sciences · 2017Article
- Meiotic recombination shapes precision of pedigree- and marker-based estimates of inbreeding.Heredity · 2017Article
- Highly Polymorphic Microsatellite Markers for the Assessment of Male Reproductive Skew and Genetic Variation in Critically Endangered Crested Macaques (International journal of primatology · 2017Article
- Low incidence of inbreeding in a long-lived primate population isolated for 75 years.Behavioral ecology and sociobiology · 2017Article
- Genomics advances the study of inbreeding depression in the wild.Evolutionary applications · 2016Review
- Fitness consequences of polymorphic inversions in the zebra finch genome.Genome biology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most molecular measures of inbreeding do not measure inbreeding at the scale that is most relevant for understanding inbreeding depression-namely the proportion of the genome that is identical-by-descent (IBD). The inbreeding coefficient FPed obtained from pedigrees is a valuable estimator of IBD, but pedigrees are not always available, and cannot capture inbreeding loops that reach back in time further than the pedigree. We here propose a molecular approach to quantify the realized proportion of the genome that is IBD (propIBD), and we apply this method to a wild and a captive population of zebra finches (Taeniopygia guttata). In each of 948 wild and 1057 captive individuals we analyzed available single-nucleotide polymorphism (SNP) data (260 SNPs) spread over four different genomic regions in each population. This allowed us to determine whether any of these four regions was completely homozygous within an individual, which indicates IBD with high confidence. In the highly nomadic wild population, we did not find a single case of IBD, implying that inbreeding must be extremely rare (propIBD=0-0.00094, 95% CI). In the captive population, a five-generation pedigree strongly underestimated the average amount of realized inbreeding (FPed=0.013<propIBD=0.064), as expected given that pedigree founders were already related. We suggest that this SNP-based technique is generally useful for quantifying inbreeding at the individual or population level, and we show analytically that it can capture inbreeding loops that reach back up to a few hundred generations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.