ArticleOrigins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life2014
Two perspectives on the origin of the standard genetic code.
Article in Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Self-similarity and the maximum entropy principle in the genetic code.Theory in biosciences = Theorie in den Biowissenschaften · 2023Article
- Thawing out frozen metabolic accidents.BMC biology · 2019Review
- Frozen Accident Pushing 50: Stereochemistry, Expansion, and Chance in the Evolution of the Genetic Code.Life (Basel, Switzerland) · 2017Article
- Pathways of Genetic Code Evolution in Ancient and Modern Organisms.Journal of molecular evolution · 2015Review
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Authors and funding
3 authors.
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Abstract
The origin of a genetic code made it possible to create ordered sequences of amino acids. In this article we provide two perspectives on code origin by carrying out simulations of code-sequence coevolution in finite populations with the aim of examining how the standard genetic code may have evolved from more primitive code(s) encoding a small number of amino acids. We determine the efficacy of the physico-chemical hypothesis of code origin in the absence and presence of horizontal gene transfer (HGT) by allowing a diverse collection of code-sequence sets to compete with each other. We find that in the absence of horizontal gene transfer, natural selection between competing codes distinguished by differences in the degree of physico-chemical optimization is unable to explain the structure of the standard genetic code. However, for certain probabilities of the horizontal transfer events, a universal code emerges having a structure that is consistent with the standard genetic code.
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Registered trials
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